T2toxin

T2toxin

a trichothecene toxin (a secondary toxic metabolite) produced by a number of Fusarium spp. fungi including F. tricinctum growing on stored grain usually maize corn. The toxin affects rapidly dividing cells, thereby causing necrosis of skin and of cells lining the alimentary tract, lymphoid and hemopoietic tissues. This may result in panleukopenia and defective blood clotting. The toxin is also a teratogen and causes stillbirth, abortion and fetal abnormalities. Clinical signs include feed refusal and vomiting in species that can vomit. Called also moldy corn disease. See also trichothecene.