As expected, high-glucose-inhibited T1R2 and T1R3 expression in SV-40 MES 13 cells (Figure 4(b)) and HK-2 cells (Figure 4(c)) was obviously reversed by lactisole in a dose-dependent manner (p < 0.05).
Previous research showed that the intestinal STRs, T1R2 and T1R3, were expressed in distinct epithelial cells in the human proximal intestine and that their transcript levels varied with glycemic status in patients with type 2 diabetes [11, 19].
It is quite likely that a major component of the STRs may be a homodimer of T1R3 .
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Ohtsu et al., "Lactisole inhibits the glucose-sensing receptor T1R3 expressed in mouse pancreatic [beta]-cells," Journal of Endocrinology, vol.
Representative images of immunohistochemistry (a) and immunofluorescence (b) staining showed that T1R2 and T1R3 expression was downregulated in renal tissue of DM mouse models.
Scientists estimated that even low levels of environmental chemicals (e.g., phenoxyauxin herbicides) or drugs (e.g., lipid-lowering fibrates) that are T1R3 (sweet taste receptor) inhibitors could lower sperm count and negatively influence human male fertility, while activators of sweet taste receptors may help male fertility [85, 223].
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