TAS1R3

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TAS1R3

A gene on chromosome 1p36.33 that encodes a G protein-coupled receptor which acts a putative taste receptor: TAS1R1/TAS1R3 responds to the umami taste stimulus (the taste of monosodium glutamate); TAS1R2/TAS1R3 recognises diverse natural and synthetic sweeteners.
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As expected, high-glucose-inhibited T1R2 and T1R3 expression in SV-40 MES 13 cells (Figure 4(b)) and HK-2 cells (Figure 4(c)) was obviously reversed by lactisole in a dose-dependent manner (p < 0.05).
Previous research showed that the intestinal STRs, T1R2 and T1R3, were expressed in distinct epithelial cells in the human proximal intestine and that their transcript levels varied with glycemic status in patients with type 2 diabetes [11, 19].
It is quite likely that a major component of the STRs may be a homodimer of T1R3 [26].
Jinhui et al., "Expression of the glucose-sensing receptor T1R3 in pancreatic islet: changes in the expression levels in various nutritional and metabolic states," Endocrine Journal, vol.
Ohtsu et al., "Lactisole inhibits the glucose-sensing receptor T1R3 expressed in mouse pancreatic [beta]-cells," Journal of Endocrinology, vol.
Representative images of immunohistochemistry (a) and immunofluorescence (b) staining showed that T1R2 and T1R3 expression was downregulated in renal tissue of DM mouse models.
Scientists estimated that even low levels of environmental chemicals (e.g., phenoxyauxin herbicides) or drugs (e.g., lipid-lowering fibrates) that are T1R3 (sweet taste receptor) inhibitors could lower sperm count and negatively influence human male fertility, while activators of sweet taste receptors may help male fertility [85, 223].
Breer, "T1R3 is expressed in brush cells and ghrelin-producing cells of murine stomach," Cell and Tissue Research, vol.
Taniguchi, "Expression of the sweet receptor protein, T1R3, in the human liver and pancreas," Journal of Veterinary Medical Science, vol.
Tincello, "Expression and distribution of the sweet taste receptor isoforms T1R2 and T1R3 in human and rat bladders," Journal of Urology, vol.
Toyono et al., "Muscle regulatory factors regulate T1R3 taste receptor expression," Biochemical and Biophysical Research Communications, vol.
Mosinger, "Phenoxyherbicides and fibrates potently inhibit the human chemosensory receptor subunit T1R3," Journal of Medicinal Chemistry, vol.