T-cell

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Related to T-cells: Cytokines, B-cells

T-cell

or

helper T-cell

a type of LYMPHOCYTE produced in bone marrow and differentiating in thymus tissue, that counteracts the presence of foreign ANTIGENS by a process of cell-mediated immunity in which the antigen is slowly destroyed by the T-cell or by a toxin released from the T-cells. The ‘priming’ of the T-cell to a specific antigen and the long-term growth of activated T-cells is thought to be influenced by INTERLEUKINS produced by MACROPHAGES.
References in periodicals archive ?
Then different DNA is added to the T-Cells in that blood - it's a bit like plugging a USB stick into your computer to install new software.
[USA], May 18 (ANI): Researchers have shown how skin vaccination can produce protective CD8 T-cells that are recruited to the genital tissues and could be used as a vaccination strategy for sexually transmitted infections (STIs).
As an example, the introduction of a CAR construct in T-cells induces cross T-cell reaction and leads to their self-destruction during manufacturing.
A comparison of healthy controls and patients with severe sepsis revealed significant differences in the percentages of Tregs in total CD4+ T-cells (mean, 4.97 vs.
They realized that cancer cells were somehow putting a brake on the killer T-Cells and making them ineffective.
Cancer is notoriously wily, and when T-cells crawl into a tumor, the tumor tends to switch off the T-cells' cancer-killing abilities.
In another study, researchers from the University of Florida created a gene therapy that stimulates Tregs to curb self-reactive effector T-cells, thereby protecting myelin.
Therefore, there is a need to establish the optimal treatment strategy, that is, the one which both maximizes the patient's uninfected [CD4.sup.+] T-cells and minimizes the harmful side effects due to the drugs.
[CD4.sup.+] T-cells were isolated from the spleens of H37Ra-infected mice using a MACS column.
Novartis CAR-T, tisagenlecleucel, works by reprogramming T-cells to recognize CD19, a protein that's expressed in B-cell cancers, including ALL.
It has been found that HIV targets and infects [CD4.sup.+] T-cells. This is because [CD4.sup.+] Tcells have a protein on its surface that can bind to foreign substances such as HIV, that is, through exploitation of the CCR5 and CXCR4 coreceptors expressed on their surfaces.
Current methods using antiretroviral therapies (ART) fall short of ridding patients of HIV, as the virus can hide out of the drugs' reach in the immune system's T-cells.