T-cell receptor


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T-cell re·cep·tor

(TCR) (sel rĕ-sep'tŏr)
An adhesion molecule on the membrane of T lymphocytes, which serves as the receptor for antigen bound to antigen-presenting cells (APC) through MHC molecules. It is expressed in a complex with CD3. It is in proximity to the MHC-restricted receptor (CD4 or CD8).
Synonym(s): T-lymphocyte antigen receptor.

T-cell receptor

Abbreviation: TCR
One of two polypeptide chains (a or ß) on the surface of T lymphocytes that recognize and bind foreign antigens. TCRs are antigen specific; their activity depends on antigen processing by macrophages or other antigen-presenting cells and the presence of major histocompatibility complex proteins to which peptides from the antigen are bound.
See: autoimmunity; immune response; T cell
See also: receptor
References in periodicals archive ?
Lck SH3 domain function is required for T-cell receptor signals regulating thymocyte development.
[4] Nonstandard abbreviations: SCID, severe combined immunodeficiency; TREC, T-cell receptor excision circle; NBS, newborn screening.
ACTengine involves genetically engineering a patient's own T cells to express novel T-cell receptors which are specific to Immatics' XPRESIDENT targets.
Using T-cell receptors (TCRs) that are closely associated with the CD3 complex on their surface, [gamma]/[delta] T cells provide instant defense against pathogens in a nonspecific way at those sites.
The companies entered a research collaboration and licensing agreement in January 2014 to develop novel cancer therapies using Immunocore's Immune Mobilizing Monoclonal T-Cell Receptor Against Cancer (ImmTAC) technology.
The study found that the killer T-cell receptor utilises an abnormal mode of binding in order to recognise cells producing insulin.
It is thought that this process gives rise to a phenomenon known as T-cell receptor promiscuity, which could be responsible for harmful effects T-cells can sometimes cause.
In the case patient, a T-cell receptor [gamma] locus (TCR[gamma]) gene rearrangement assay was the molecular test performed on the intestinal biopsy specimens to test for the presence of a clonal population of T cells.
It has been well established in the scientific literature that at least two signals are required for T-cell activation and that, if only one signal is supplied to T-cells without the ability of the same T-cells to receive a second activation signal, these T-cells undergo "programmed cell death." The AdapT molecular constructs capitalize on this well known principle and "work" by engaging the antigen-specific T-cell receptor with one of its peptides and, at the same time, block and inhibit the second signal needed for the full activation of these disease causing T-cells.
Reverse transcriptase-polymerase chain reaction can detect tumor markers in malignant cells in the form of specific chromosomal translocations (such as Philadelphia chromosome in chronic myeloid leukemia) and mutations (such as rearrangement of the T-cell receptor in non-Hodgkin's lymphoma).
Polymerase chain reaction testing showed that he did have a T-cell receptor gene rearrangement, but his lymphocytes were normal; so there was no evidence of cutaneous T-cell lymphoma.
Riether volunteered in a clinical study of the effects of a T-cell receptor vaccine on MS, and her symptoms improved.

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