T-cell lymphomas


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mature T-cell neoplasms

A group of neoplasms defined by the WHO classification (first published in 2001 and updated in 2008, which draws their parentage from the REAL (Revised European American Lymphoma) classification), which groups lymphomas by cell type (i.e., the normal cell type that most resembles the tumour) and defining phenotypic, molecular or cytogenetic characteristics.

Mature T cell neoplasms
▪ T-cell prolymphocytic leukaemia.
▪ T-cell large granular lymphocytic leukaemia.
▪ Adult T-cell leukaemia/lymphoma.
▪ Extranodal NK/T cell lymphoma, nasal type.
▪ Enteropathy-type T-cell lymphoma.
▪ Hepatosplenic T-cell lymphoma.
▪ Mycosis fungoides (Sezary syndrome).
▪ Primary cutaneous CD30-positive T-cell lymphoproliferative disorders.
▪ Primary cutaneous anaplastic large cell lymphoma.
▪ Lymphomatoid papulosis.
▪ Angioimmunoblastic T-cell lymphoma.
▪ Peripheral T-cell lymphoma, unspecified.
▪ Anaplastic large cell lymphoma.

T-cell lymphoma

A malignant proliferation of T cells arising in the skin, diagnosed by detecting rearrangement of the T-cell receptor's β chain; TCLs are often 'driven' by EBV and other viral infections; 90% of all Pts with TCL have extracutaneous involvement when diagnosed. See Mycosis fungoides.
T-cell lymphomas
Small lymphocytic (well-differentiated lymphocyte-like) lymphoma–13%
Convoluted cell lymphoma or poorly-differentiated lymphocytic lymphoma–52%
Immunoblastic sarcoma or 'histiocytic' lymphoma–19%
Mycosis fungoides/Sézary syndrome–11%
Lymphoepithelial cell (Lennert's) lymphoma–5%
Cutaneous T-cell lymphoma
HTLV (I, II)–induced lymphoma
References in periodicals archive ?
Although some authors describe the infiltrates of primary cutaneous acral [CD8.sup.+] T-cell lymphoma as more monomorphic than those of primary cutaneous small/medium-sized pleomorphic cutaneous T-cell lymphoma, the 2 entities may be morphologically indistinguishable.
The T-cell lymphoma component which showed CD4+++; CD10+++; PD1++; Bcl-6++, suggestive of the follicular T-helper cell phenotype, was most consistent with AITL.
Reed-Sternberg-like cells in T-cell lymphomas typically present with a B-cell immunophenotype.
Additionally, HSTL also needs to be differentiated from nonhepatosplenic [gamma]/[delta] T-cell lymphomas, such as type II EATL.
Primary cutaneous follicular variant of peripheral T-cell lymphoma NOS: a report of two cases.
Allogeneic transplantation following a reduced-intensity conditioning regimen in relapsed/refractory peripheral T-cell lymphomas: Long-term remissions and response to donor lymphocyte infusions support the role of a graft-versus-lymphoma effect.
Enteropathy-type T-cell lymphoma. In: Jaffe ES, Harris NL, Stein H, Vardiman JW.
Intragumtornchai et al., "Clinical differences between nasal and extranasal natural killer/T-cell lymphoma: a study of 136 cases from the international peripheral T-cell lymphoma project," Blood, vol.
While recent developments, such as immunotherapies, have turned the once fatal diagnosis of B-cell lymphoma into a curable condition, BBC News notes that T-cell lymphoma is much rarer and often more aggressive.
Nodal involvement by cutaneous CD30-positive T-cell lymphoma mimicking classical Hodgkin lymphoma.
Forero-Torres et al., "Brentuximab vedotin in the front- line treatment of patients with CD30+ peripheral t-cell lymphomas: results of a phase I study," Journal of Clinical Oncology, vol.
T-cell lymphomas have a more aggressive course [1], and most of the patients often initially visit at stage 3 or 4.