T-cell lymphomas

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T-cell lymphomas,

a heterogenous group of lymphoid tumors representing malignant transformation of the T lymphocytes. Some types of tumors formerly included in this group have been found to be mixtures of T cells and B cell precursors.

mature T-cell neoplasms

A group of neoplasms defined by the WHO classification (first published in 2001 and updated in 2008, which draws their parentage from the REAL (Revised European American Lymphoma) classification), which groups lymphomas by cell type (i.e., the normal cell type that most resembles the tumour) and defining phenotypic, molecular or cytogenetic characteristics.

Mature T cell neoplasms
▪ T-cell prolymphocytic leukaemia.
▪ T-cell large granular lymphocytic leukaemia.
▪ Adult T-cell leukaemia/lymphoma.
▪ Extranodal NK/T cell lymphoma, nasal type.
▪ Enteropathy-type T-cell lymphoma.
▪ Hepatosplenic T-cell lymphoma.
▪ Mycosis fungoides (Sezary syndrome).
▪ Primary cutaneous CD30-positive T-cell lymphoproliferative disorders.
▪ Primary cutaneous anaplastic large cell lymphoma.
▪ Lymphomatoid papulosis.
▪ Angioimmunoblastic T-cell lymphoma.
▪ Peripheral T-cell lymphoma, unspecified.
▪ Anaplastic large cell lymphoma.

T-cell lymphoma

A malignant proliferation of T cells arising in the skin, diagnosed by detecting rearrangement of the T-cell receptor's β chain; TCLs are often 'driven' by EBV and other viral infections; 90% of all Pts with TCL have extracutaneous involvement when diagnosed. See Mycosis fungoides.
T-cell lymphomas
Small lymphocytic (well-differentiated lymphocyte-like) lymphoma–13%
Convoluted cell lymphoma or poorly-differentiated lymphocytic lymphoma–52%
Immunoblastic sarcoma or 'histiocytic' lymphoma–19%
Mycosis fungoides/Sézary syndrome–11%
Lymphoepithelial cell (Lennert's) lymphoma–5%
Cutaneous T-cell lymphoma
HTLV (I, II)–induced lymphoma
References in periodicals archive ?
CDT) Poster Title: "Pralatrexate in Patients with Relapsed/Refractory Peripheral T-cell Lymphoma (PTCL): Relationship Between Response and Survival" First Author: Andrei R.
Gloucester Pharmaceuticals develops new therapies that address the unmet medical needs in the treatment of cancer, including cutaneous T-cell lymphoma (CTCL), peripheral T-cell lymphoma (PTCL) and other hematological malignancies.
In this Phase 1/2 Memorial Sloan Kettering sponsored study, patients with aggressive non-Hodgkin's lymphoma (diffuse large B- or T-cell lymphoma, mantle cell lymphoma, transformed large cell lymphomas) or Hodgkin's Disease are administered increasing doses of PDX with vitamin B12 and folic acid supplementation.
HuMax-CD4 Currently in Phase III Clinical Trial for Cutaneous T-Cell Lymphoma and Phase II Clinical Trial for Non-Cutaneous T-Cell Lymphoma
There is an urgent medical need to treat non-cutaneous T-cell lymphoma patients who presently have no approved treatment options and a short life expectancy.
Over the past year, Gloucester has presented the final pivotal data for romidepsin in cutaneous T-cell lymphoma and compiled and submitted the NDA for this promising drug candidate while also advancing a second pivotal program in peripheral T-cell lymphoma and recently completing a significant Series D financing.
Genmab is running two Phase II studies concurrently using HuMax-CD4 to treat cutaneous T-cell lymphoma (CTCL), one in early stage patients and the other for patients with advanced disease.
Gloucester has filed a New Drug Application (NDA) for romidepsin in cutaneous T-cell lymphoma (CTCL) that is under review with the U.
Vose J, Armitage J, Weisenburger D; International T-Cell Lymphoma Project.
Companies discussed in this Peripheral T-Cell Lymphomas (PTCL) -- Pipeline Review, H1 2015 report include AB Science, Affimed Therapeutics AG, Bayer AG, Celgene Corporation, Eisai Co.
Enteropathy-associated T-cell lymphoma (EATL)--classic and type II forms--are recognized by the World Health Organization classification scheme as a tumor of intraepithelial T-cells.
Withal it is a useful book, and having the less often discussed associations such as T-cell lymphomas and leiomyosarcomas assigned a place alongside authoritative chapters on the classic associations, nasopharyngeal carcinoma and Burkitt lymphoma, is convenient.