T-cell lymphomas


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T-cell lymphomas,

a heterogenous group of lymphoid tumors representing malignant transformation of the T lymphocytes. Some types of tumors formerly included in this group have been found to be mixtures of T cells and B cell precursors.

mature T-cell neoplasms

A group of neoplasms defined by the WHO classification (first published in 2001 and updated in 2008, which draws their parentage from the REAL (Revised European American Lymphoma) classification), which groups lymphomas by cell type (i.e., the normal cell type that most resembles the tumour) and defining phenotypic, molecular or cytogenetic characteristics.

Mature T cell neoplasms
▪ T-cell prolymphocytic leukaemia.
▪ T-cell large granular lymphocytic leukaemia.
▪ Adult T-cell leukaemia/lymphoma.
▪ Extranodal NK/T cell lymphoma, nasal type.
▪ Enteropathy-type T-cell lymphoma.
▪ Hepatosplenic T-cell lymphoma.
▪ Mycosis fungoides (Sezary syndrome).
▪ Primary cutaneous CD30-positive T-cell lymphoproliferative disorders.
▪ Primary cutaneous anaplastic large cell lymphoma.
▪ Lymphomatoid papulosis.
▪ Angioimmunoblastic T-cell lymphoma.
▪ Peripheral T-cell lymphoma, unspecified.
▪ Anaplastic large cell lymphoma.

T-cell lymphoma

A malignant proliferation of T cells arising in the skin, diagnosed by detecting rearrangement of the T-cell receptor's β chain; TCLs are often 'driven' by EBV and other viral infections; 90% of all Pts with TCL have extracutaneous involvement when diagnosed. See Mycosis fungoides.
T-cell lymphomas
Small lymphocytic (well-differentiated lymphocyte-like) lymphoma–13%
Convoluted cell lymphoma or poorly-differentiated lymphocytic lymphoma–52%
Immunoblastic sarcoma or 'histiocytic' lymphoma–19%
Mycosis fungoides/Sézary syndrome–11%
Lymphoepithelial cell (Lennert's) lymphoma–5%
Cutaneous T-cell lymphoma
HTLV (I, II)–induced lymphoma
References in periodicals archive ?
Primary cutaneous T-Cell lymphomas showing gamma-delta ([gamma][delta]) phenotype and predominantly epidermotropic pattern are clinicopathologically distinct from classic primary cutaneous [gamma][delta] T-Cell lymphomas.
The report reviews pipeline therapeutics for Peripheral T-Cell Lymphomas (PTCL) by companies and universities/research institutes based on information derived from company and industry-specific sources
A review of the Peripheral T-Cell Lymphomas (PTCL) products under development by companies and universities/research institutes based on information derived from company and industry-specific sources
Gemmill, "Cutaneous T-cell lymphoma," Seminars in Oncology Nursing, vol.
Enteropathy-associated T-cell lymphomas have a cytotoxic T-cell phenotype.
The results are only suggestive, he added, because of the small number of cases of T-cell lymphoma, and the researchers' inability to determine lymphoma subtype in a majority of cases.
All 14 samples with clinical, histologic, and immunohistochemical evidence of T-cell lymphoma showed either a single, monoclonal peak or a very prominent monoclonal peak in a polyclonal background.
Nasdaq: SGEN) today announced results from a phase I clinical trial of ADCETRIS (brentuximab vedotin) in combination with chemotherapy for the treatment of newly diagnosed mature T-cell lymphoma (MTCL) patients, including patients with systemic anaplastic large cell lymphoma (sALCL).
Peripheral T-cell lymphomas with RS-like cells represent one of the most challenging differential diagnosis of classical Hodgkin lymphomas because of the characteristic mixed inflammatory background seen in both entities.
Nasal T-cell lymphomas respond well to local radiation therapy.
Because of similar clinical presentation, morphology, and immunophenotype, HSTL must be distinguished from the following lymphoid neoplasms: aggressive NK-cell leukemia, T-cell large granular lymphocytic leukemia (T-LGL), T-lymphoblastic leukemia (T-LBL), other peripheral T-cell lymphomas, splenic marginal zone lymphoma, and hairy cell leukemia.
ClickPress, Wed Aug 21 2013] Global Markets Direct's, 'Peripheral T-Cell Lymphomas (PTCL) - Pipeline Review, H2 2013', provides an overview of the indication's therapeutic pipeline.