T-cell depletion

T-cell depletion

A therapeutic manoeuvre (e.g., diphtheria toxin injection), which is meant to reduce T cells that play a key role in immune response. T-cell depletion of a donor’s bone marrow graft reduces the risk of graft versus host disease (GVHD).
References in periodicals archive ?
Before ART initiation, HIV infection and immune activation may lead to CD4+ T-cell depletion, lymphoid tissue fibrosis, and decreased thymic output,[sup][10],19,[31],[32],[33] and all of these factors may lead to a decrease in naive CD4+ T-cell reservoir.
The 25HC also reversed the T-cell depletion caused by HIV.
T-cell depletion first occurs at the mucosal level, where the majority of lymphocytes (i.
Severe CD4+ T-cell depletion in gut lymphoid tissue during primary human immunodeficiency virus type 1 infection and substantial delay in restoration following highly active antiretroviral therapy.
The justification for treating AHI is to preserve specific anti-HIV immune responses, reduce morbidity associated with high viraemia and CD4+ T-cell depletion and reduce the risk of HIV transmission.
Such infections have been observed in rapid progressors, in which CD4+ T-cell depletion is so swift that B cells receive no T-cell help and are therefore not able to mount an effective immune response (7).
It occurs more commonly in symptomatic than asymptomatic children and is a marker for moderate to severe CD4 T-cell depletion.
Data from simian modeling with simian immunodeficiency virus show that T-cell depletion in the gut occurs very rapidly in infection, and that early treatment can preserve some of these memory T cells, which may allow better immune-system control of HIV over a longer term.
An additional provocative suggestion associated with the gut CD4 T-cell depletion theory is that HIV's early impact on the gut compromises the integrity of the gut surface, allowing the "friendly" bacteria that aid digestion to leak into the system, thereby provoking an immune response and causing systemic immune activation.
In his opening statement the plaintiff's attorney David Breskin argued the patients should have received more information about the experimental treatment which centered on T-cell depletion, the Associated Press reported.
49,50) From these observations, it can be deduced that while the Fas/FasL pathway may be important in the apoptosis of T lymphocytes in HIV infection, there appears to be other pathways that contribute to T-cell depletion in vivo.
In addition, CDC has received reports of five persons from three states who have had persistently low CD4+ T-cell levels but who have had no evidence of HIV infection or underlying disease processes or therapies known to be associated with T-cell depletion.
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