T-cell


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Related to T-cell: T-cell receptor, Cutaneous T-cell Lymphoma, T-cell lymphoma

T-cell

or

helper T-cell

a type of LYMPHOCYTE produced in bone marrow and differentiating in thymus tissue, that counteracts the presence of foreign ANTIGENS by a process of cell-mediated immunity in which the antigen is slowly destroyed by the T-cell or by a toxin released from the T-cells. The ‘priming’ of the T-cell to a specific antigen and the long-term growth of activated T-cells is thought to be influenced by INTERLEUKINS produced by MACROPHAGES.
References in periodicals archive ?
SEATTLE, May 8, 2015 /PRNewswire/ -- Adaptive Biotechnologies, the leader in next generation sequencing (NGS) to profile T- and B-cell receptors of the adaptive immune system, and its collaborators will present data demonstrating how profiling a patient's T-cell repertoire may lead to diagnostic and therapeutic discovery in immune-mediated diseases at the American Association of Immunologists (AAI) Annual Meeting in New Orleans from May 8-11, 2015.
The aim of this research project is to develop new glycan-based nanomedicines targeted to DC to induce powerful T-cell responses.
The study presented at the International Liver Congress 2014 detected and expanded MHC-multimer-positive CD8+ T-cells specific for targeted GPC3 epitopes and grew T-cell clones, from which the most specific and active T-cell receptor was isolated.
Enteropathy-associated T-cell lymphoma comprises 10% to 25% of all primary lymphomas of the small intestine, and it is the most common malignancy associated with celiac disease.
Scientists at the University were able to solve the molecular structure of the enhanced T-cell receptor, bound to a fragment from a melanoma cell.
1) Extranodal natural killer T-cell (NK/T-cell) lymphoma, which is extremely rare and highly aggressive, mainly affects the nasopharyngeal area and the nasal cavity; when it occurs in other remote sites, the prognosis is usually unfavorable.
T-cell receptor gene rearrangement studies were positive in 25 out of 26 evaluated cases (96%).
JPT offers four delivery options for T-cell assays: 1) Fast Track for proteome-wide T-cell epitope discovery programs 2) Research Track for T-cell epitope mapping studies 3) Discovery Track for immune monitoring applications and 4) Trial Track for vaccination trials.
New treatments, now under development, aim at blocking the functions of the T-cell receptor and the CD28 molecule in order to dampen attacks on the nervous system.
This small molecule drug is being developed for treatment of T-cell malignancies, and has been designated an "Orphan Drug" for broader indications, including cutaneous T-cell lymphoma (CTCL), chronic lymphocytic leukemia (CLL) and acute lymphoblastic leukemia (ALL), by the FDA.
National Institute of Allergy and Infectious Diseases (NIAID) reported that an experimental vaccine clearly improved the survival of monkeys after infection by SIV (simian immunodeficiency virus), a virus similar to HIV--even though it did not prevent infection, and did not much improve viral load or total T-cell count.
Data from a clinical trial presented at the American Society of Hematology 46th Annual Meeting and Exposition (ASH) demonstrated MabCampath (alemtuzumab) was effective in the first-line treatment of peripheral T-cell non Hodgkin's Lymphoma (NHL).