therapy needs an antigen target that is abundant on cancer cells and not found on normal cells.
One of the challenges in treating T-cell
lymphomas has been finding a way to eliminate the abnormal T-cells
while sparing the healthy ones.
lymphoma typically occurs in adults older than 50 years, with a slight male predominance.
In June 2016, Adaptimmune Therapeutics received orphan drug designation from Europe for its NY-ESO SPEAR (Specific Peptide Enhanced Affinity Receptor) T-cell
therapy for fighting soft tissue sarcoma.
leukemia/lymphoma (ATLL) is a malignant tumor of mature T-cells
caused by the human T-cell
lymphotropic virus type-1 (HTLV-1), which responds poorly to chemotherapy.
Antiretroviral therapy (ART) has transformed the lives of millions of persons infected with HIV by gradually increasing their CD4+ T-cell
counts over a decade.
The availability of cGMP grade T-Cell
reagents significantly expands the complete solution that our customers need to bring cell therapies into widespread clinical practice.
This report provides comprehensive information on the therapeutic development for Peripheral T-Cell
Lymphomas (PTCL), complete with comparative analysis at various stages, therapeutics assessment by drug target, mechanism of action (MoA), route of administration (RoA) and molecule type, along with latest updates, and featured news and press releases.
Primary small intestinal lymphoma maybe broadly categorized into three groups including immunoproliferative small intestinal disease (IPSID) lymphoma, enteropathy-associated T-cell
lymphoma (EATL) and other western-type non-IPSID lymphomas.
The study presented at the International Liver Congress 2014 detected and expanded MHC-multimer-positive CD8+ T-cells
specific for targeted GPC3 epitopes and grew T-cell
clones, from which the most specific and active T-cell
receptor was isolated.
A snapshot of the global therapeutic scenario for Peripheral T-Cell
Scientists at the University were able to solve the molecular structure of the enhanced T-cell
receptor, bound to a fragment from a melanoma cell.