T-cell


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T-cell

or

helper T-cell

a type of LYMPHOCYTE produced in bone marrow and differentiating in thymus tissue, that counteracts the presence of foreign ANTIGENS by a process of cell-mediated immunity in which the antigen is slowly destroyed by the T-cell or by a toxin released from the T-cells. The ‘priming’ of the T-cell to a specific antigen and the long-term growth of activated T-cells is thought to be influenced by INTERLEUKINS produced by MACROPHAGES.
References in periodicals archive ?
Any T-cell therapy needs an antigen target that is abundant on cancer cells and not found on normal cells.
One of the challenges in treating T-cell lymphomas has been finding a way to eliminate the abnormal T-cells while sparing the healthy ones.
T-cell lymphoma typically occurs in adults older than 50 years, with a slight male predominance.
In June 2016, Adaptimmune Therapeutics received orphan drug designation from Europe for its NY-ESO SPEAR (Specific Peptide Enhanced Affinity Receptor) T-cell therapy for fighting soft tissue sarcoma.
Adult T-cell leukemia/lymphoma (ATLL) is a malignant tumor of mature T-cells caused by the human T-cell lymphotropic virus type-1 (HTLV-1), which responds poorly to chemotherapy.
Antiretroviral therapy (ART) has transformed the lives of millions of persons infected with HIV by gradually increasing their CD4+ T-cell counts over a decade.
The availability of cGMP grade T-Cell reagents significantly expands the complete solution that our customers need to bring cell therapies into widespread clinical practice.
This report provides comprehensive information on the therapeutic development for Peripheral T-Cell Lymphomas (PTCL), complete with comparative analysis at various stages, therapeutics assessment by drug target, mechanism of action (MoA), route of administration (RoA) and molecule type, along with latest updates, and featured news and press releases.
Primary small intestinal lymphoma maybe broadly categorized into three groups including immunoproliferative small intestinal disease (IPSID) lymphoma, enteropathy-associated T-cell lymphoma (EATL) and other western-type non-IPSID lymphomas.
The study presented at the International Liver Congress 2014 detected and expanded MHC-multimer-positive CD8+ T-cells specific for targeted GPC3 epitopes and grew T-cell clones, from which the most specific and active T-cell receptor was isolated.
A snapshot of the global therapeutic scenario for Peripheral T-Cell Lymphomas (PTCL).
Scientists at the University were able to solve the molecular structure of the enhanced T-cell receptor, bound to a fragment from a melanoma cell.