TBX3

(redirected from T-box 3)

TBX3

A gene on chromosome 12q24.1 that encodes a DNA-binding member of the phylogenetically conserved family of genes that have a common DNA-binding domain, the T-box. T-box genes encode transcription factors involved in regulating development; TBX3 is a transcriptional repressor and thought to play a role in orienting the anterior/posterior axis of the tetrapod forelimb.

Molecular pathology
TBX3 mutations cause ulnar-mammary syndrome, which affects limb, apocrine gland, tooth, hair and genital development.
References in periodicals archive ?
Other SNPs that reached genome-wide significance were rs401681 and rs2736098 near the TERT (telomerase reverse transcriptase) gene on chromosome 5, rs10788160 near the FGFR2 (fibroblast growth factor receptor 2) gene, rs10993994 near the MSMB (microseminoprotein, beta-) gene (as in prior studies) on chromosome 10, rs11067228 near the TBX3 (T-box 3) gene on chromosome 12, and rs4430796 at the HNF1B (HNF1 homeobox B) gene on chromosome 17.
[3] Human genes: KLK3, kallikrein-related peptidase 3; TERT, telomerase reverse transcriptase; FGFR2, fibroblast growth factor receptor 2; MSMB, microsemino- protein, beta-; TBX3, T-box 3; HNF1B, HNF1 homeobox B.