VA-E application resulted in a disappearance of primary QoL association (personality and social) with T helper cells
(r > -0.
Antigen Express is working to develop technology that increases the antigen-specific stimulation of T helper cells.
Stimulation of T helper cells is negligible with this method, because antigens normally need to be obtained from outside cells (via phagocytized bacteria, for example) to be processed for T helper stimulation.
In the body, immune cells called CD4 T helper cells
produce a host of proteins, including interleukin-4, that orchestrate the response to invaders.
Secondly, AE37 works through a portion of the immune system, represented by the T helper cells, that has been largely overlooked up to now in developing cancer immunotherapy strategies.
Robert Humphreys, founder of Antigen Express, who was first to identify both MHC class II molecules and their role in stimulating T helper cells as well as a portion of the Ii protein capable of dramatically increasing the response of T helper cells to specific antigenic epitopes.
They had known about T helper cells
, so called because they prod other lymphocytes to act, and cytotoxic T cells, which attack and destroy undesirable cells.
These transgenic mice contain the human HLA-DR molecules, which presented the vaccine peptides to the mouse T helper cells
The transgenic mice used in this model contain the human HLA-DR molecules which present the vaccine peptides to mouse T helper cells
Without T helper cells
there was essentially no response to the therapy, while the addition of T helper cells
back to the mix of stimulated lymphocytes re-infused into the patient resulted in nearly a 50% response rate," continued Dr.
David Hafler (both Yale University, New Haven and the Broad Institute of the Massachusetts Institute of Technology, MIT, and Harvard University, USA) observed changes in CD4 positive T helper cells
(Th) in humans, which were associated with specific dietary habits.
Cathy Blackwell presented: "Enhanced T Helper Cell
Epitope Peptide Vaccines for Melanoma.