T helper cell


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T helper cell

see helper lymphocyte.
References in periodicals archive ?
Robert Humphreys, founder of Antigen Express, who was first to identify both MHC class II molecules and their role in stimulating T helper cells as well as a portion of the Ii protein capable of dramatically increasing the response of T helper cells to specific antigenic epitopes.
noticed that two types of T helper cells exist in mice, each associated with a distinctive bouquet of chemical messengers.
In retrospect, having two kinds of T helper cells makes a lot of sense.
T helper cells are the sergeants that roust T or B cells into action.
The reason for this lack of potency stems in part from the fact that those vaccine peptides do not boost T helper cells, which up-regulate the cytotoxic T lymphocytes and provide long-term immunological memory.
The mechanism used by Antigen Express scientists to stimulate T helper cells has been to create a hybrid linking the peptide recognized by T-helper cells through a simple chemical linker to an immunoregulatory segment of the Ii-protein (the Ii-Key peptide).
Thus, Ii-Key/melanoma hybrids for T helper cells can be used in combination with cytotoxic T lymphocyte epitope peptides for maximal clinical therapeutic effect.
from the HER-2/neu cancer-related antigen) that force them to be presented to T helper cells by MHC class II molecules, which are the immune system's gatekeeper for antigen-specific T helper stimulation.