Several companies are now testing an approach that uses a synthetic gene
to replace the faulty dystrophin gene which causes Duchenne.
Nobel Prize winner Har Gobind Khorana, an Indian-American biochemist who was credited with discovery of essential function of the DNA and construction of the first synthetic gene
, was honored by Google in form of a doodle on Tuesday.
Application of revised techniques in diverse biological processes should permit the optimization of gene therapy, metabolic flux, and synthetic gene
Data shows that Anc80-AAV, an in silico-designed synthetic gene
therapy vector, has the potential to provide superior gene expression levels in retina, liver, muscle, cochlea's outer hair cells and other tissue targets in preclinical studies, as well as reduced cross-reactivity as compared to naturally occurring adeno-associated viral vectors (AAVs) that are currently in clinical development.
and the bacterial expression vector (pET-15b) were digested with NdeI and BamHI enzymes (Fermentas, EU), and the ligation step was performed using Rapid DNA Ligation Kit (Fermentas, EU).
In Fussenegger's opinion, it is a real breakthrough that a synthetic gene
network has been successfully used to achieve genetic reprogramming that delivers beta cells.
The synthetic gene
and pJIT163 vector were restricted with EcoRI and HindIII (Fermentas) restriction enzymes at 37C for 1 h.
Network: Modeling, Analysis, and Robust Design Methods
The free software tools proposed in literature include, for instance, GeMS (web-based application, ), Optimizer (web-based application, ), Synthetic Gene
Designer (web-based application, ), and Gene Designer (stand-alone application, ).
Washington, Oct 16 ( ANI ): A new research has found that a synthetic gene
module controlled by the happiness hormone dopamine produces an agent that lowers blood pressure.
In early theoretical work, his team showed how synthetic gene
circuits could steer stem cells to develop into insulin-producing cells.
Arctic Apples will be generally equivalent to regular apples, except for a synthetic gene
that is a duplicate of its own genes which activates a self-defense mechanism known as RNA interference that shuts down the genes responsible forthe production of discoloration-causingpolyphenol oxidase.