triamcinolone(redirected from Synthetic corticosteroid)
Also found in: Dictionary, Thesaurus, Encyclopedia.
triamcinolone/tri·am·cin·o·lone/ (tri″am-sin´o-lōn) a synthetic glucocorticoid used in replacement therapy for adrenocortical insufficiency and as an antiinflammatory and immunosuppressant in a wide variety of disorders.
A synthetic glucocorticoid, C21H27FO6, used, usually in acetal or acetate forms, in the treatment of a wide variety of inflammatory and allergic conditions.
indications It is prescribed topically as an antiinflammatory agent in the treatment of dermatoses, stomatitis, and lichen planus lesions, is inhaled for the treatment of allergies and asthma, is injected (e.g., into joints) for the treatment of local inflammation, and is taken orally in low doses for treatment of adrenocortical insufficiency and in higher antiinflammatory/immunosuppressive doses for the treatment of systemic diseases such as systemic lupus erythematosus.
contraindications Fungal infections or known hypersensitivity to this drug prohibits its systemic use. Viral or fungal infections of the skin, impaired circulation, or known hypersensitivity to this drug prohibits its topical use.
adverse effects Among the more serious adverse effects to the systemic administration of the drug are GI, endocrine, neurological, fluid, and electrolyte disturbances. Skin reactions may occur from topical administration of this drug.
triamcinoloneA CORTICOSTEROID drug used to treat inflammatory disorders, ASTHMA, THROMBOCYTOPENIA and some forms of LEUKAEMIA. Brand names are Adcortyl, Adcortyl in Orabase, Kenalog, Lederspan and Nasacort. Triamcinolone is also an ingredient is a range of preparations for external use.
A drug which inhibits or suppresses most inflammatory responses of an allergic, bacterial, traumatic or anaphylactic origin, as well as being immunosuppressant. They include the corticosteroids (e.g. betamethasone, dexamethasone, fluorometholone, hydrocortisone acetate, loteprednol etabonate, prednisolone, rimexolone, triamcinolone). They are sometimes combined with an antibiotic drug (e.g. betamethasone combined with neomycin or sulfacetamide, dexamethasone combined with neomycin or polymyxin B). Corticosteroids have side effects, such as enhancing the activity of herpes simplex virus, fungal overgrowth, raising intraocular pressure or cataract formation.There are other antiinflammatory drugs that are non-steroidal (NSAID) and have little toxicity. They act mainly by blocking prostaglandin synthesis. These include diclofenac sodium, flurbiprofen sodium, indomethacin, ketorolac, nepafenac and oxyphenbutazone. See immunosuppressants; steroid.
A chronic inflammatory lipogranuloma due to retention of the secretion (such as blocked ducts) of a meibomian gland in the tarsus of an eyelid. It is characterized by a gradual painless swelling of the gland without marked inflammatory signs and sometimes astigmatism which is induced by the cyst pressing on the cornea (Fig. C5). Small chalazia may disappear spontaneously but large ones usually have to be incised and curetted (i.e. removal of the pus with a scraper) through a tarsal incision. Resolution may also occur after local injection of a corticosteroid drug (e.g. dexamethasone or triamcinolone). Syn. meibomian cyst (although it is not a true cyst because its walls are made of granulomatous tissue and not lined with epithelium). See internal hordeolum.
n a synthetic adrenocorticosteroid that has a potent antiinflammatory effect and is used topically in the treatment of angular cheilosis.
a prednisolone derivative used as an anti-inflammatory glucocorticoid in the form of the acetonide derivative and the diacetate ester.