synovial sarcoma

(redirected from Synovial cell sarcoma)
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syn·o·vi·al sar·co·ma

a rare malignant tumor of synovial origin, most commonly involving the knee joint and composed of spindle cells usually enclosing slits or pseudoglandular spaces that may be lined by radially disposed epitheliallike cells.
Farlex Partner Medical Dictionary © Farlex 2012

synovial sarcoma

A mesenchymal spindle cell tumour which comprises ±10% of all soft-tissue sarcomas. It is most common in young (age 20 to 40) males, and occurs most commonly around the large joints—knee, ankle, foot, 60% in the legs, 23% in upper extremity. However, it can go any place, as cases have been reported in the penis, lung, vulva, abdominal wall, etc.

Prognosis
50% 5-year survival; extensively calcified synovial sarcomas have a higher (84%) 5-year survival; 40% metastasise to lungs, bone-regional nodes.

Good prognostic factors
Children; < 5cm; <10 mitoses/10hpf; no necrosis; complete excision in first attempt.
 
Adverse prognosticators
Older age, larger size (especially, > 35 cm), necrosis, vascular invasion, high Ki-67 index, high-grade nuclei, poorly differentiated areas, known recurrence.

Synovial sarcoma, histologic types
Biphasic
• Distinct epithelial and spindle cell components.
 
DiffDx
Mesothelioma, carcinosarcoma.

Monophasic

DiffDx, Spindle cell type
Malignant peripheral-nerve sheath tumour, schwanoma, solitary fibrous tumour, fasciitis.

DiffDx, Glandular cell type
Any adenocarcinoma.

Poorly differentiated

DiffDx
Ewing sarcoma and other small round cell tumours.
Segen's Medical Dictionary. © 2012 Farlex, Inc. All rights reserved.

synovial sarcoma

Surgery A mesenchymal malignancy that comprises ±10% of all soft tissue tumors; it is most common in young–age 20-40 ♂, knee, ankle, foot, etc Prognosis 50% 5-yr survival; extensively calcified SSs have a higher–84% 5-yr survival. See Sarcoma, Soft tissue tumors.
McGraw-Hill Concise Dictionary of Modern Medicine. © 2002 by The McGraw-Hill Companies, Inc.
References in periodicals archive ?
Tumour Size Predicts Prognosis of Head and Neck Synovial Cell Sarcoma. Oncol Let 2015; 9(1): 381-86.
Sharma, "Primary synovial cell sarcoma of the heart: a rare case," Heart Views, vol.
Price, "Clinicopathologic factors and adjuvant treatment effects on survival in adult head and neck synovial cell sarcoma," Head and Neck, vol.
Awareness of intraosseous synovial cell sarcoma and its poor prognosis is needed among orthopaedic surgeons and pathologist because this tumour can present in uncommon sites and mimic common infective pathologies leading to delay in treatment.
However, solid or semi-solid pathologies (such as synovial cell sarcoma, synovial hemangioma, or synovial chondromatosis) can have similar signal intensity.
We report two cases of sarcoma that required resection of the entire thumb metacarpal, including one chondrosarcoma and one synovial cell sarcoma. Both were treated by resection and autograft arthrodesis of the proximal phalanx of the thumb to the shaft of the second metacarpal.
Synovial cell sarcoma: Diagnosis, treatment, and outcomes.
(1) A histologic resemblance has been found between the neural cells of malignant peripheral nerve sheath tumor and synovial cell sarcoma. (1) The pathophysiology involves a gene translocation abnormality t(X;18) (p11.2;q11.2).
Emily was diagnosed with Synovial cell sarcoma in 2000.
A new phase II trial suggests that an immunotherapy strategy called adoptive cell transfer (ACT) may be effective for patients with metastatic melanoma and synovial cell sarcoma. The study is part of a larger effort by researchers at the National Cancer Institute to engineer a patient's own white blood cells to recognize and attack his or her own cancer.
He was diagnosed with Synovial Cell Sarcoma two years ago and has already lost an arm and part of a lung which was riddled with 41 tumours.