synaptosome

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syn·ap·to·some

(sin-ap'tō-sōm),
Membrane-bound sac containing synaptic vesicles that breaks away from axon terminals when brain tissue is homogenized under controlled conditions; such particles can be separated from other subcellular particles by differential and density gradient centrifugation.
[synapse + G. sōma, body]

synaptosome

(sĭ-năp′tə-sōm′)
n.
Any of various sacs, composed of synaptic vesicles and mitochondria, that break away from axon terminals at a synapse after brain tissue has been homogenized under controlled conditions.

syn·ap′to·so′mal adj.

syn·ap·to·some

(si-nap'tŏ-sōm)
Membrane-bound sac containing synaptic vesicles that breaks away from axon terminals when brain tissue is homogenized under controlled conditions; such particles can be separated from other subcellular particles by differential and density gradient centrifugation.
[synapse + G. sōma, body]
References in periodicals archive ?
Bonan, "Effects of inhibitory avoidance training and/or isolated foot-shock on ectonucleotidase activities in synaptosomes of the anterior and posterior cingulate cortex and the medial precentral area of adult rats," Behavioural Brain Research, vol.
The synaptosomes cultured on the coverglass were incubated with 2 [micro]M Fura-2/AM for 20 min at room temperature.
In vitro evaluation of neurotoxicity potential and oxidative stress responses of diazinon and its degradation products in rat brain synaptosomes. Toxicol Lett 233:29-37.
The animals when preliminarily treated with 7-N showed a significant attenuation of the COC withdrawal symptoms, and their brain-isolated synaptosomes displayed both the reversal of the drug mitochondrial depression and the decrease of GSH levels [72].
Davey, "Partial inhibition of complex I activity increases [Ca.sup.2+]-independent glutamate release rates from depolarized synaptosomes," Journal of Neurochemistry, vol.
Risso et al., "Effects of adenosine A1 and A2A receptor activation on the evoked release of glutamate from rat cerebrocortical synaptosomes," British Journal of Pharmacology, vol.
Wang, "Mechanisms underlying the riluzole inhibition of glutamate release from rat cerebral cortex nerve terminals (synaptosomes), "Neuroscience, vol.
Balch, "Differential regulation of exocytosis by calcium and CAPS in semi- intact synaptosomes," Neuron, vol.
Dopaminergic D2 receptor binding using rat striatum synaptosomes were performed as previously described (12).
For example, leptinotarsin, isolated and identified from the Colorado potato beetle, has been shown to disrupt the release of acetylcholine at the presynaptic nerve terminal of rat synaptosomes (Yoshino et al., 1980).
Toxins from cone snails such as [omega]-conotoxin MVIIA or Ziconotide, initially purified as SNX-111, is a potent reversible blocker of N type calcium channels (OLIVERA et al., 1985), capable to inhibit, in synaptosomes, neurotransmitters release such as norepinephrine (BOWERSOX et al., 1995) and glutamate (GONCAVES et al., 2011), essential in the development of secondary spinal injury.
Lehmann A, Hamberger A: Effects of taurine on calcium binding and accumulation in rabbit hippocampal and cortical synaptosomes. Neurochem Int.