synaptic plasticity

(redirected from Synaptic efficacy)

synaptic plasticity

 Physiology Malleability present in synapses in various forms–eg, presynaptic inhibition, homosynaptic depression, presynaptic facilitation and modulation of transmitter release by tonic depolarization of sensory neuron. See Neuroplasticity, Nitric oxide.
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To bring the ultimate goal of developing a brain-machine-spinal-cord interface (BMSI) device for functional recovery after SCI to fruition, this project will establish the appropriate parameters for stimulating the spinal cord and increasing synaptic efficacy using brain activity after SCI.
In our model, even weak and spatially localized input from the hippocampus influenced the spatiotemporal pattern of slow oscillations and led to a persistent change of synaptic efficacy between neurons," Wei said.
18) The calyx of Held is a typical, high-fidelity fast glutamatergic synapse, with strong synaptic efficacy and precise neurotransmission with synchronous transmitter release, contributing to sound localization by detecting inter-aural differences in sound intensity.
In the striatum, the net effect of chronic ethanol has been less well studied, but the work to date indicates that ethanol exposure brings about an LTP-like enhancement of synaptic efficacy at glutamatergic synapses that transmit signals to striatal MSNs.
Regulation of synaptic efficacy by coincidence of postsynaptic APs and EPSPs.
Increases in phosphorylation of the extracellular regulated protein kinase (ERK), a subfamily of MAPKs alter synaptic efficacy and learning and memory.
This property, known as synaptic efficacy, can be adjusted by the brain as part of the process of encoding information.
Based on the general idea that the selection of behavior implies physiological modification, it is argued that this modification consists of an increase in synaptic efficacy between neurons.
Beyond all-or-none action potentials, subthreshold synaptic and membrane electric activity in neurons disclose the details of single-neuron computations, neuronal identity and role, information processing and synaptic readout, as well as history-dependent dynamics of excitability and synaptic efficacy.
2+] influx (using these data of Blaustein and Ector), again indicating a significant reduction in transmitter secretion and, accordingly, in synaptic efficacy.
This use-dependent change in synaptic efficacy is induced by conjunctive stimulation of parallel and climbing fibers (Crepel et al.
Long-term potentiation (LTP) is a widely used paradigm for increasing synaptic efficacy, and the induction of one form of LTP requires the activation of NMDA receptors (Collingride and Daries, 1989).