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Few physicians choose Symbyax because of side effects--the weight gain and metabolic effects, he added.
Symbyax is fine to use for 6-8 weeks, but no one knows if long-term use might destabilize patient mood.
Symbyax is marketed by Lilly USA and is approved for the acute treatment of treatment-resistant depression and bipolar I depression in adults.
The only approved drug treatment for bipolar depression is a combination of olanzapine and fluoxetine marketed as Symbyax.
The regulatory clearance of Eli Lilly and Co.'s Symbyax for TRD marks a milestone for the pharmaceutical company.
The letter also pointed out a change in the labeling of olanzapine (as well as Symbyax, an olanzapine and fluoxetine combination drug approved in December for the treatment of bipolar depression) indicating the addition of a warning that cerebrovascular adverse events, including fatalities, were reported in patients in trials of olanzapine use in elderly patients with dementia.
The combination product was approved by the Food and Drug Administration in December and is marketed under the brand name of Symbyax, by Eli Lilly & Co., its manufacturer.
Such major products in established lines as Gemzar, an anticancer drug, and Humalog, an injectable insulin, should perform well, and sales increases are also expected from such newer products as Forteo for severe osteoporosis; Alimta, an oncology agent; Symbyax for bipolar depression; and Cymbalta, an antidepressant.
Nausea and diarrhea are more common with Symbyax therapy.
Lurasidone * Latuda Mirtazapine * Remeron Moclobemide * Amira, Aurorix, Clobemix, Depnil, Manerix Modafinil * Provigil Olanzapine/fluoxetine * Symbyax Paroxetine * Paxil Phenelzine * Nardil Pramipexole * Mirapex Quetiapine * Seroquel Riluzole * Rilutek Sertraline * Zoloft Vortioxetine * Brintellix
It will be marketed as Symbyax by Eli Lilly & Co., the manufacturer of both drugs.