Acute febrile neutrophilic dermatosis, previously called
Sweet syndrome, is an uncommon condition characterized by fever, elevated neutrophil count, and tender, red, cutaneous papules, plaques, or nodules.
Adding the history of fever, laboratorial abnormalities, and the histologic findings on skin biopsy, a component of the
Sweet Syndrome was assumed.
He said he had symptoms of
Sweet Syndrome: lack of appetite, loss of weight, itchiness of the skin, pain in the joints.
Rybojad et al., "Chronic recurrent lymphocytic
sweet syndrome as a predictive marker of myelodysplasia: A report of 9 cases," JAMA Dermatology, vol.
The relationship between neutrophilic dermatosis of the dorsal hands and
Sweet syndrome: report of 9 cases and comparison to atypical pyoderma gangrenosum.
During the previous 5 years, he had received multiple immunomodulatory drugs for treatment of natural killer cell deficiency, hyper-IL-6 syndrome, recurrent polychondritis, and
Sweet syndrome. His medications were prednisone (42.5 mg/d), intravenous immunoglobulin (400 mg/kg monthly), and subcutaneous canakinumab (180 mg every 8 weeks, which began 3 weeks before onset of symptoms).
Sweet syndrome (acute febrile neutrophilic dermatosis) is a disorder of unknown etiology.
(1-4) Nocardiosis, specifically, has been reported in the literature in patients receiving infliximab for conditions such as Crohn's disease, psoriasis,
Sweet syndrome, and rheumatoid arthritis.
[8] Kou et al have reported a male with underlying lepromatous leprosy presenting with atypical reactional state simulating
sweet syndrome. [9] A fatal case of erythema necroticans, the cause of death being septicemia secondary to skin ulcers and URTI ENL has been reported by Sethuraman et al and Petro et al.
Once diagnosis is reached treatment is generally initiated to target any underlying diseases that include inflammatory bowel disease gammopathies paraproteinemias leukemias Behcet disease
Sweet syndrome hepatitis HIV systemic lupus erythematosus and vasculitides.5
Sweet syndrome is a neutrophilic dermatosis typically accompanied by fever, neutrophilia, and increased erythrocyte sedimentation rate.
