Acute febrile neutrophilic dermatosis, previously called Sweet syndrome
, is an uncommon condition characterized by fever, elevated neutrophil count, and tender, red, cutaneous papules, plaques, or nodules.
Adding the history of fever, laboratorial abnormalities, and the histologic findings on skin biopsy, a component of the Sweet Syndrome
He said he had symptoms of Sweet Syndrome
: lack of appetite, loss of weight, itchiness of the skin, pain in the joints.
Rybojad et al., "Chronic recurrent lymphocytic sweet syndrome
as a predictive marker of myelodysplasia: A report of 9 cases," JAMA Dermatology, vol.
The relationship between neutrophilic dermatosis of the dorsal hands and Sweet syndrome
: report of 9 cases and comparison to atypical pyoderma gangrenosum.
During the previous 5 years, he had received multiple immunomodulatory drugs for treatment of natural killer cell deficiency, hyper-IL-6 syndrome, recurrent polychondritis, and Sweet syndrome
. His medications were prednisone (42.5 mg/d), intravenous immunoglobulin (400 mg/kg monthly), and subcutaneous canakinumab (180 mg every 8 weeks, which began 3 weeks before onset of symptoms).
(acute febrile neutrophilic dermatosis) is a disorder of unknown etiology.
(1-4) Nocardiosis, specifically, has been reported in the literature in patients receiving infliximab for conditions such as Crohn's disease, psoriasis, Sweet syndrome
, and rheumatoid arthritis.
 Kou et al have reported a male with underlying lepromatous leprosy presenting with atypical reactional state simulating sweet syndrome
.  A fatal case of erythema necroticans, the cause of death being septicemia secondary to skin ulcers and URTI ENL has been reported by Sethuraman et al and Petro et al.
Once diagnosis is reached treatment is generally initiated to target any underlying diseases that include inflammatory bowel disease gammopathies paraproteinemias leukemias Behcet disease Sweet syndrome
hepatitis HIV systemic lupus erythematosus and vasculitides.5
is a neutrophilic dermatosis typically accompanied by fever, neutrophilia, and increased erythrocyte sedimentation rate.