surrogate marker


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Related to surrogate marker: bioequivalence trial

surrogate marker

EBM
A parameter (e.g., diastolic blood pressure) used to assess a drug's biological activity, which may serve as indicator of efficacy of a therapeutic agent, rather than a more serious but less common clinical endpoint, such as death.
Segen's Medical Dictionary. © 2012 Farlex, Inc. All rights reserved.

surrogate marker

Lab medicine A parameter or measured to detect a pathologic condition when a more specific test doesn't exist, is impractical or not cost-effective; surrogate testing has been used for non-A, non-B hepatitis, measuring ALT and antibodies to HBV core antigen–anti-HBc and HC
McGraw-Hill Concise Dictionary of Modern Medicine. © 2002 by The McGraw-Hill Companies, Inc.

surrogate marker

An indirect indicator of a disease state or of its response to therapy. Such markers often include laboratory tests thought to represent clinical progress accurately. For example, in diabetes mellitus, the glycosylated hemoglobin level is used as a marker of glycemic control; in AIDS the level of HIV RNA is used as a marker of disease progression.
See also: marker
Medical Dictionary, © 2009 Farlex and Partners
References in periodicals archive ?
Evidence for the "fitness" effect comes from the temporal association between loss of resistance phenotype and the steepest changes in surrogate markers. Studies by Stephen Deeks and colleagues have also given credence to this hypothesis.
Though such strong correlation in short term (3 month) follow up used in this study is an indicator of usefulness of albumin as a surrogate marker but for further assessment of its effect on mortality needs a longer duration of follow up in a bigger study cohort as had been shown before in the study done by Mehta et al.
Overall, we believe that our findings support the potential use of qPCR to detect the presence of [bIa.sub.OXA-23] gene directly from ETAs, and possibly the detection of other carbapenemase-encoding genes, such as [bIa.sub.OXA-143] gene for example, which has been shown to be highly prevalent in some Brazilian Southeastern cities, (5) as surrogate marker for the presence or absence of CRAB in patients under mechanical ventilation.
Nevi counts are associated with UV exposure, and can be used as a surrogate marker for UV-induced cutaneous damage.
In a commentary, the CDC noted that prior research has shown that norovirus can be transmitted to fomites and that a surrogate marker for norovirus, feline calcivirus, has been shown to survive on computer mouses and keyboards for up to 2 days.
In other words, was the endpoint chosen for the study correct for the condition being studied (i.e., an objective marker or validated surrogate marker).
Low levels of WNV antibodies in nestlings could serve as a surrogate marker of exposure in adult raptor populations.
Birth weight is a gross surrogate marker for shifts in a host of metabolic processes.
Sometimes the therapy itself may alter the predictive value of a surrogate marker. For example, Steven Deeks, MD, has shown that HIV-infected patients who remain on a protease inhibitor do better clinically than their viral loads would indicate.
The treatment certainly did increase HIV-specific immunity as shown by lymphocyte proliferation assay (p[less than]001), [2] but this measure is not currently accepted as a surrogate marker of drug efficacy, because there is no proof at this time that increasing this response is clinically beneficial to patients.
Historical rates do not exceed 50% in this disease setting; serum levels of antigen-specific IgG, against both individual WT1 peptides within GPS and the full-length WT1 protein, were induced in 86% of patients; achievement of high titers of WT1-specific IgG post-GPS results from Immunoglobulin M to IgG class switching, the latter being a surrogate marker of induction of activated T-helper cells after vaccination.
Thus, keeping TLC as the main surrogate marker, monitoring Haemoglobin, Body Mass Index and Serum albumin levels will provide us a sensitive low cost prediction of the CD4 count along with the progression of the disease in HIV/AIDS.