surrogate marker(redirected from Surrogate endpoint)
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A parameter (e.g., diastolic blood pressure) used to assess a drug's biological activity, which may serve as indicator of efficacy of a therapeutic agent, rather than a more serious but less common clinical endpoint, such as death.
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surrogate markerLab medicine A parameter or measured to detect a pathologic condition when a more specific test doesn't exist, is impractical or not cost-effective; surrogate testing has been used for non-A, non-B hepatitis, measuring ALT and antibodies to HBV core antigen–anti-HBc and HC
McGraw-Hill Concise Dictionary of Modern Medicine. © 2002 by The McGraw-Hill Companies, Inc.
An indirect indicator of a disease state or of its response to therapy. Such markers often include laboratory tests thought to represent clinical progress accurately. For example, in diabetes mellitus, the glycosylated hemoglobin level is used as a marker of glycemic control; in AIDS the level of HIV RNA is used as a marker of disease progression.
See also: marker
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