surfactant protein A


Also found in: Wikipedia.

surfactant protein A

a protein secreted by alveolar type II cells in the lung that regulates the secretion of surfactant, among other things.
References in periodicals archive ?
Structure, genetics and function of the pulmonary associated surfactant protein A and D: The extra-pulmonary role of these C type lectins.
Serum surfactant protein A levels in healthy individuals are increased in smokers.
Saenz et al., "Surfactant protein A prevents IFN-[gamma]/IFN-[gamma] receptor interaction and attenuates classical activation of human alveolar macrophages," The Journal of Immunology, vol.
In recent years, experimental studies have emphasized that specific pulmonary bioindicators considered to be secreted from deteriorated lung tissue, such as surfactant protein A (SP-A), surfactant protein D (SP-D), Krebs von den Lungren-6 (KL-6), and Clara cell protein (CC-16), are effective in determining lung deterioration severity (29-31).
Among the shared proteins were some of the most prominent blood and BAL proteins: albumin, serotransferrin, surfactant protein A (SP-A), [[alpha].sub.1]-antitrypsin, and immunoglobulins (13).
Surfactant protein A (SP-A) may regulate the secretion and exocytosis of surfactant from the type II cell, as well as the re-uptake of surfactant for recycling and re-use.
Effect of hydroxylation and N187-linked glycosylation on molecular and functional properties of recombinant human surfactant protein A. Biochemistry 42:9532-9542.
Hallman, "Association between the surfactant protein A (SP-A) gene locus and respiratory-distress syndrome in the Finnish population," American Journal of Human Genetics, vol.
Human surfactant protein A (SP-A) may play a role in inflammation by modulating cytokine production by macrophages.