About 50 years ago, the importance of primary surfactant deficiency
in the pathogenesis of neonatal RDS was found by Avery and Mead (4).
Further investigations in this area should focus on the study of the molecular and genetic mechanisms of synthesis and transport of surfactant proteins, and to develop simple inexpensive methods for detection of the lungs surfactant deficiency
In the neonatal period, pulmonary oedema is often mistaken for primary pulmonary pathology such as surfactant deficiency
syndrome (hyaline membrane disease), transient tachypnea of the newborn or infection on chest radiographs.
Survanta was given 100 mg/kg (4mL/kg) in four divided doses and was indicated if the infant weighed < 1,250 g, had suspected surfactant deficiency
, the risk of RDS or the physician opted to rescue an infant with RDS.