hepatitis B serology

(redirected from Surface Antigen)
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hepatitis B serology

Hepatitis B serological markers Lab medicine A generic term referring to hepatitis B antigens and antibodies to these antigens
Hepatitis B serology
Core antigen The HBc particle that contains double-stranded DNA and DNA polymerase, and is associated with the HBe antigen; HBc is not directly detected by currently-used assays; its presence indicates persistently replicating hepatitis B virus
Core antibody A long-term serologic marker for HBV, with 2 antibodies
IgM HBcAb A marker of acute infection, which rises early–within 2-4 weeks of HBV infection and slowly disappears; ↓ levels of IgM HBcAb indicate resolving infection; IgM HBcAb is the best serologic marker for acute HBV infection
IgG HBcAb A 'convalescent' antibody that indicates prior HBV infection; it rises 4-6 months after infection and persists for life, especially in those with active liver disease; partially protective anti-HBc antibody levels can be induced by recombinant vaccination, but are short-lived
e antigen An antigen that rises and falls parallel to HBsAg, and derives from the proteolytic cleavage of the nucleocapsid; its presence implies a carrier state
e antibody Anti-HBe An antibody that rises as HBe falls, appearing in convalescent Pts, persisting for up to several years after resolution of hepatitis
Surface antigen HBsAg The first marker to appear after HBV infection, preceding clinical disease by weeks, peaking with the onset of symptoms and disappearing six months post-infection; as long as HBsAg is positive, the Pt is considered infectious and must follow prescribed sanitary procedures to avoid infecting others; if the hepatitis does not resolve, HBsAg persists and can be detected for many years or life.
Antibody to surface antigen HBsAb, anti-HBs, antibody to surface antigen HBsAb begins to rise as the HBsAg falls; it is detectable 8-10 weeks post infection, is regarded as being protective against re-infection, and persists for life; HBsAb is formed after using the HBV vaccine, and is not present in the chronic phase of the disease.  
References in periodicals archive ?
Hepatitis B surface antigens are an early sign of an acute infection, and they are also present during chronic, or long-term, infection.
For the remaining 10 patients, HB surface antigen status was either not known or baseline HBV could not be interpreted.
The report provides a snapshot of the global therapeutic landscape for Tumor Necrosis Factor Receptor Superfamily Member 5 (B-Cell Surface Antigen CD40 or CD40L Receptor or CD40)
Seroprevalence of Hepatitis B surface antigen, antibodies to Hepatitis C virus and human immunodeficiency virus in a hospital-based population in Jaipur, Rajasthan.
Furthermore, it also aids in reducing the incidence of perinatal transmission of hepatitis B virus, and formulating hepatitis B immunoprophylaxis to all new born infants of hepatitis B surface antigen positive mothers.
The tests included Hepatitis B surface antibodies (anti HBs), Hepatitis B surface antigen (HBsAg) and Hepatitis B e antigen (HBeAg) which were performed on ARCHITECT of Abbott using "Microparticle enzyme Immunoassay" ELISA.
14-16 The national prevalence study of Pakistan showed hepatitis B surface antigen (HBsAg) positivity to be 2.
Sero-clearance of hepatitis B surface antigen in chronic carriers does not necessarily imply a good prognosis.
An estimated 90%-95% of healthy adults aged 40 years and younger achieve a protective antibody titer (defined as anti-hepatitis B surface antigen concentrations of 10 mIU/mL or greater) after receiving the three-dose series (MMWR2011;60[RR07]:l-45).