hepatitis B serology

(redirected from Surface Antigen)
Also found in: Acronyms.

hepatitis B serology

Hepatitis B serological markers Lab medicine A generic term referring to hepatitis B antigens and antibodies to these antigens
Hepatitis B serology
Core antigen The HBc particle that contains double-stranded DNA and DNA polymerase, and is associated with the HBe antigen; HBc is not directly detected by currently-used assays; its presence indicates persistently replicating hepatitis B virus
Core antibody A long-term serologic marker for HBV, with 2 antibodies
IgM HBcAb A marker of acute infection, which rises early–within 2-4 weeks of HBV infection and slowly disappears; ↓ levels of IgM HBcAb indicate resolving infection; IgM HBcAb is the best serologic marker for acute HBV infection
IgG HBcAb A 'convalescent' antibody that indicates prior HBV infection; it rises 4-6 months after infection and persists for life, especially in those with active liver disease; partially protective anti-HBc antibody levels can be induced by recombinant vaccination, but are short-lived
e antigen An antigen that rises and falls parallel to HBsAg, and derives from the proteolytic cleavage of the nucleocapsid; its presence implies a carrier state
e antibody Anti-HBe An antibody that rises as HBe falls, appearing in convalescent Pts, persisting for up to several years after resolution of hepatitis
Surface antigen HBsAg The first marker to appear after HBV infection, preceding clinical disease by weeks, peaking with the onset of symptoms and disappearing six months post-infection; as long as HBsAg is positive, the Pt is considered infectious and must follow prescribed sanitary procedures to avoid infecting others; if the hepatitis does not resolve, HBsAg persists and can be detected for many years or life.
Antibody to surface antigen HBsAb, anti-HBs, antibody to surface antigen HBsAb begins to rise as the HBsAg falls; it is detectable 8-10 weeks post infection, is regarded as being protective against re-infection, and persists for life; HBsAb is formed after using the HBV vaccine, and is not present in the chronic phase of the disease.  
References in periodicals archive ?
Introduction of the new ARCHITECT hepatitis B surface antigen assay is another milestone in Abbott's 40-year history of achievement in hepatitis diagnostics.
This prevalence rate, determined only by surface antigen serology, may be falsely low as HBV DNA has been commonly reported in HIV-seropositive patients with isolated core antibody.
The translational products of the surface antigen gene consist of 3 proteins that have different initiation sites with the same termination site.
Immunodiagnostic Products Anti-HBs Reagent Pack and Calibrators (VITROS Anti-HBs assay) is for the qualitative in vitro determination of total antibody to hepatitis B surface antigen (anti-HBs) in human serum using the VITROS ECi Immunodiagnostic System.
Contract awarded for surface antigen of hepatitis b virus
In addition, the proposed category B recommendation states that "revaccination with three additional doses of hepatitis B vaccine generally increases the proportion of [nonresponding] adults who achieve a protective level of antibody to hepatitis B surface antigen.
Hepatitis B isolation rooms used to dialyze hepatitis B surface antigen positive patients should not be used for these patients unless: 1) the patient with suspected or confirmed novel H1N1 influenza virus is hepatitis B surface antigen positive or 2) the facility has no hepatitis B surface antigen positive patients who would require treatment in the isolation room.
Hepatitis B surface antigen (HBsAg) is an HBV serologic marker that plays a major role in the diagnosis of HBV infection.
Dynavax has had an agreement with Berna for supply of hepatitis B surface antigen for use with HEPLISAV, its hepatitis B vaccine.
1]-lysine albumin adducts and hepatitis B surface antigen.
According to earlier studies, nearly all Taiwanese children who have liver cancer also test positive for a hepatitis B surface antigen, as do 70 to 80 percent of adults with liver cancer.