Suramine | definition of Suramine by Medical dictionary
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suramin A derivative of urea which has currency as an antiparasitic and been used to manage trypanosomiasis and onchocerciasis. Suramin was evaluated by the US National Cancer Institute for managing prostate cancer, but was dropped from its research in 2008.
Suramin has been used by alternative health practitioners as a cancer therapy, based on its ability to block enzyme activity and the production of growth factors. It has been used for leukaemia, as well as cancers of the adrenal cortex, breast, kidney and prostate; its effect may be enhanced by adding tumour necrosis factor and/or interferon-gamma to the therapeutic regimen.
References in periodicals archive
However the activity of compound 1 is lower than the activity of suramine
and pentamidine, drugs used for treatment of sleeping sickness.
Receptor function can be abrogated by utilizing monoclonal antibodies against receptors such as [alpha]IR3 (26), use of polyanionic compound suramine
(45), or exploiting antisense oligodeoxynucleotides directed against the IGF-R1 mRNA.
With the exception of antimalarials, there are currently only four drugs (suramine
developed in 1921; pentamidine developed in 1941; melarsoprol developed in 1949 and eflornithine developed in 1990) approved to treat HAT (Mackey et al.