ABCC10

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ABCC10

A gene on chromosome 6p21.1 that encodes a protein of the MRP subfamily of the superfamily of ATP-binding cassette (ABC) transporters, which transport various molecules across extra- and intracellular membranes, many of which are involved in multidrug resistance. ABCC10 is an ATP-dependent transporter, which may be involved in cellular detoxification by extruding lipophilic anion.
References in periodicals archive ?
Furthermore, the shiftwork-induced deficits in sleep homeostasis and circadian rhythms may lead to different psychiatric disorders and affect SUR2 gene, which was found involved in energy metabolism and aetiology of cardiomyopathies [41].
The channel contains a regulatory subunit, composed of the ABCC8 or ABCC9 (ATP-binding cassette, subfamily C members 8 and 9) gene products referred to as sulfonylurea receptor 1 and 2 (SUR1 and SUR2) proteins [2], respectively.
SUR1 and SUR2 are so named because an important drug class, the sulfonylureas, bind to, and block, activity.
Tolbutamide and gliclazide block channels containing SUR1 ([beta]-cell type) but not SUR2 (cardiac, smooth muscle types), whereas glibenclamide, glimepiride, repaglinide, and meglitinide block both types of the channels [104].
Besides pancreatic beta cells these channels are present in various tissues of the body including cardiomyocytes and vascular smooth muscle cells (SUR2 isoform).
Two Kir6.x (Kir6.1 and Kir6.2) and two SURx (SUR1 and SUR2) subunits have been identified, and their various combinations can give rise to different functional [K.sub.ATP] channel subtypes [18].
The Skills Enhancement for Health Surveillance Program Online Modules EPI1 Basic Epidemiological Concepts EPI2 Measurement of Health Status EPI3 Epidemiological Methods APP1 Outbreak Investigation and Management APP2 Epidemiology of Chronic Diseases APP3 Applied Epidemiology: Injuries SUR1 Introduction to Surveillance SUR2 Communicating Data Effectively STA1 Basic Biostatistics Table 2.
While the coefficient on the interaction between FDI and financial depth alone in SUR2 and SUR4 is positive but not statistically significant, we find that the coefficient on FDI x FinDepth significantly positive and coefficient on FDI x [FinDepth.sup.2] significantly negative in SUR3 and SUR5-8.
The other subunits of this channel namely [K.sub.IR]6.1 and SUR2 are coded by the genes KCNJ8 and ABCC9, respectively.
However, whilst an SUR2 splice variant lacking exon 17 has been identified in mice which had a 2-fold reduction in sensitivity to ATP compared to the full-length isoform (15), a study using rat SUR1[DELTA]17 found no differences in sensitivity to MgATP between the mutant and wild-type channels (6).
Bellini, "Sur2 mutations of Arabidopsis thaliana define a new locus involved in the control of auxin homeostasis," The Plant Journal, vol.