superficial spreading melanoma

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su·per·fi·cial spread·ing mel·a·no·ma

primary cutaneous melanoma characterized by intraepidermal growth extending laterally beyond the site of dermal invasion.
Farlex Partner Medical Dictionary © Farlex 2012

superficial spreading melanoma

Dermatology A melanoma, 70% of which affect Pts from age 30 to 60, especially ♀ in lower legs or trunk, as a flat lesion–radial growth phase that may be present for months to yrs, average 5-yr survival 75% Etiology Recreational suntanning. See Melanoma.
McGraw-Hill Concise Dictionary of Modern Medicine. © 2002 by The McGraw-Hill Companies, Inc.
References in periodicals archive ?
(18) For histology specific lifetime risk analyses, we restricted the analyses to the five most common histological subtypes based on World Health Organization (WHO)'s International Classification of Diseases for Oncology, 3rd Edition (ICD-O-3): nodular melanoma (NM) - 8721; lentigo maligna melanoma (LMM) - 8742; superficial spreading melanoma (SMM) - 8743; acral lentiginous melanoma (ALM) - 8744; and desmoplastic melanoma (DM) - 8745.
A 41-year-old man had a superficial spreading melanoma in situ, Clark's level I, removed from his anterior abdominal wall.
This type of melanoma is found in the same locations as superficial spreading melanoma and also frequently develops from an existing mole.
The highest incidence is in sixth decades as seen in our series.14,15 The slight female predominance is consistent with other studies.16 However, one study reported a slight male predominance.14,15 Superficial spreading melanoma was the commonest histological type in this series as expected because in India, superficial spreading melanoma and nodular melanoma are commonly found,17 acral lentiginous being rare.18
Mnemonics like "ABCD"--asymmetry, border irregularity, color variation, and diameter exceeding 6 mm--are helpful tip-offs for the more common forms of the disease, such as superficial spreading melanoma.
* Superficial spreading melanoma accounts for 50% of cases and occurs more frequently in younger adults.
If a principle like this were extensively applied, a lesion presently diagnosed as "superficial spreading melanoma" should be a posteriori classified as a "melanoma" only if the patient developed metastases or died, but regarded as "nevus" or as "atypical nevus" if the patient survived.
Figure 7 shows one version of the most common melanoma, the superficial spreading melanoma. The dark pigmentation around the outside of this melanoma is where the lesion is superficially spreading away from the center (which has lost its pigmentation).
(390,391) Superficial spreading melanoma typically arises on the back or legs, presents as an irregularly pigmented macule or plaque, and is the most common variant.
Several proof-of-principle studies showed potential applications of FISH to solve a variety of diagnostic dilemmas in the evaluation of melanocytic tumors, including differentiating blue nevus-like metastasis from blue nevus, mitotically active nevus from nevoid melanoma, and dysplastic nevus from superficial spreading melanoma. (7-12) Fluorescence in situ hybridization test abnormalities characteristic of melanoma were identified in lentiginous melanoma supporting this entity as a variant of melanoma.
Using comparative genomic hybridization, Bastian et al (9) compared 15 acral melanomas and superficial spreading melanoma, demonstrating that all acral melanomas had at least 1 (mean, 2.0) gene amplification, significantly more than the superficial spreading melanoma, in which only 2 of 15 patients (13%) had 1 amplification each.
This may occur in atrophic sun-damaged skin, such as that seen in lentigo maligna, or in addition to prominent pagetoid spread, as seen in superficial spreading melanoma. In acral sites, there may be a lentiginous proliferation of atypical melanocytes without much pagetoid spread and preservation of the epidermal pattern.

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