Sunburn Cell

Any of the single, large, often bizarre, light-coloured keratinocytes with a pyknotic nucleus and eosinophilic cytoplasm which appear scattered along the basal layer of the epidermis after exposure to UVC or UVB radiation or UVA in the presence of psoralens. Sunburn cells undergo premature and abnormal keratinization and are the result of programmed cell death—apoptosis
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(15) The proven photoprotective effects of topical and oral green tea include reducing UV-induced erythema, decreasing sunburn cell formation, and attenuating DNA damage.
(2) In the most recent study, completed in August 2009, supplementation with Lyc-O-Mato capsules, providing 10 mg of lycopene in addition to the other antioxidants found naturally in the tomato complex, reduced sunburn cell formation three-fold, as compared with the placebo (soybean oil).
Numerous other studies, she added, have shown that topical vitamin E reduces sunburn cell production, minimizes chronic UV-induced skin damage and reduces the production of cancer-causing cells.
The researchers noted minimal erythema on areas treated with resveratrate and the resveratrol derivative significantly inhibited sunburn cell formation.
(6), (12) Its high concentration of essential fatty acids, sterols, and vitamin E make it a potent antioxidant that can offer protection against skin damage such as sunburn cell formation and DNA degradation.
"First, sunburn cell formation is indicative of photo-damage to the skin, and second, depletion of Langerhans cells negatively affects the important immune function of the skin.
Histologically, topical caffeine application after a single dose of UVB more than doubled the number of apoptotic keratinocytes as evaluated by sunburn cell formation, caspase 3 cleavage and terminal deoxynucleotidyl transferase-mediated dUTP-biotin nick-end labelling (TUNEL) staining.
A recently completed double-blind, placebo-controlled study indicates that supplementation with Lyc-O-Mato tomato extract, from LycoRed, helps protect the skin against damage from UV radiation by reducing sunburn cell formation and protecting the skin's immune system by slowing down the depletion of Langerhans cells, following exposure to UVB/UVA solar simulator.
Previous studies in mice have demonstrated that green tea polyphenols afford significant protection against UVB-induced (290-320nm) sunburn reaction, histological parameters associated with UV damage to skin such as sunburn cell formation, UV-induced immunosuppression and skin cancer.
In study after study, Polypodium leucotomos has proven its ability to decrease the short-term consequences of sun exposure, such as redness and sunburn cell formation.
Contralateral ear in both cases and the forelimbs of case 2 had lesions of chronic solar dermatitis with pale staining bands of degenerated collagen along subepidermis, and the presence of few typical apoptotic keratinocytes, the so-called "sunburn cells", in the basal and stratum spinosum (Figure 4 inset).
(12) A meta-analysis from the Journal of Cosmetic Dermatology reported that topical vitamin E is effective in reducing erythema, sunburn cells, and photocarcinogenesis, and that high doses of oral vitamin E reduce chronic UV-B-induced skin damage.