Sumoylation

The covalent attachment of a small ubiquitin-related modifier (SUMO) to substrate protein, a process that is biochemically analogous to, but functionally distinct from, ubiquitination; sumoylation is critical to many different biological processes—e.g., protein localisation and stability, transcriptional activities, nucleocytoplasmic signalling and transport, genome replication, and regulation of gene expression
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Although the most common mechanism involved in epigenetics (or perhaps the one most often heard about) is that of methylation, other pretranscriptional and post-translational mechanisms include histone modification (through de/acetylation), ubiquitination, sumoylation, and RNA- and polycomb-based functions, although these are not fully understood.
Epigenetics--an introductory overview
However, NINDS senior investigator John Hallenbeck, co-senior author of the study found that a cellular process called SUMOylation goes into overdrive in a certain species of ground squirrel during hibernation.
Therapy Based on Hibernating Squirrels
BACE1 SUMOylation increases its stability and escalates the protease activity in Alzheimer's disease.
Analysis of the BACE1 and Clusterin Genes Expression Levels in Alzheimer's Disease/Alzheimer Hastaliginda BACE1 ve Clusterin Genleri Ekspresyon Seviyelerinin Analizi
LaminB1 also undergoes some forms of post-translational modifications, such as farnesylation [29], phosphorylation, glycosylation, and sumoylation [30], which are linked to the significant conformational changes of their target proteins [31].
Differential Expression of LaminB1 in the Developing Rat Cochlea
However, despite these links with human health and ageing, and the identification of many SUMOylated substrates, there is much to learn about how SUMOylation influences human health.
Investigation of the roles and regulation of SUMO in cell function and disease processes
Then, HIF-1[alpha] is accumulated in the cytoplasm under hypoxic condition rapidl and modified by sumoylation, s-nitrosylation, acetylation and phosphorylation (24).
Effect of Swimming Exercise to Cardiac PGC-1 [alpha] and HIF-1 [alpha] Gene Expression in Mice
Indeed, while acetylation and methylation are the most studied phenomena, histones are also submitted to phosphorylation, sumoylation, ubiquitination, and ribosylation.
Insights on the epigenetic mechanisms underlying pulmonary arterial hypertension
Activating transcription factor 3 SUMOylation is involved in angiotensin II-induced endothelial cell inflammation and dysfunction.
Cardiac Fibroblast-Specific Activating Transcription Factor 3 Promotes Myocardial Repair after Myocardial Infarction
The different type of histone modifications include methylation, phosphorylation, acetylation, sumoylation and ubiqutination of histones residues.
Epigenetic Alterations and their Dietary Backgrounds
Additionally, their activity is subject to regulation by posttranslational modifications, such as phosphorylation, SUMOylation, and ubiquitination (5).
Assessment of the Association Between Three Perplexing PPARA Gene Polymorphisms and the Risk of Coronary Artery Disease in a Population of Turkish Cypriot Women
SUMOylation occurs in acute kidney injury and plays a cytoprotective role.
Cytoreductive surgery plus hyperthermic intraperitoneal chemotherapy: main concepts for anesthetists/Cirugia citorreductiva y quimioterapia intraperitoneal hipertermica: Conceptos importantes para el anestesiologo
Zhou et al., "High glucose induces activation of NF-[kappa]B inflammatory signaling through I[kappa]B[alpha] sumoylation in rat mesangial cells," Biochemical and Biophysical Research Communications, vol.
AICAR-Induced AMPK Activation Inhibits the Noncanonical NF-[kappa]B Pathway to Attenuate Liver Injury and Fibrosis in BDL Rats

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