Sumoylation

The covalent attachment of a small ubiquitin-related modifier (SUMO) to substrate protein, a process that is biochemically analogous to, but functionally distinct from, ubiquitination; sumoylation is critical to many different biological processes—e.g., protein localisation and stability, transcriptional activities, nucleocytoplasmic signalling and transport, genome replication, and regulation of gene expression
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She discovered SUMOylation and promoted the SUMO field through key findings, seminal reviews, methods development, dissemination of protocols and reagents, as well as teaching and mentoring the next generation of scientists.
Germany : Frauke Melchior receives the 2018 FEBS / EMBO Women in Science Award
Tau is also extensively modified posttranslationally and has been reported to be modified by phosphorylation, acetylation, glycosylation, glycation, deamidation, isomerization, nitration, methylation, ubiquitylation, sumoylation, and truncation.
Tau-mediated Neurodegeneration and Potential Implications in Diagnosis and Treatment of Alzheimer's Disease
Recently, researchers led by John Hallenbeck found that a cellular process called SUMOylation goes into overdrive in a certain species of ground squirrel during hibernation.
Squirrels inspire new stroke treatments
Thyroid hormone receptor sumoylation is required for preadipocyte differentiation and proliferation.
Adipogenic Effects and Gene Expression Profiling of Firemaster[R] 550 Components in Human Primary Preadipocytes
Ehrlichia chaffeensis exploits host SUMOylation pathways to mediate effector-host interactions and promote intracellular survival.
Fatal monocytic ehrlichiosis in woman, Mexico, 2013
According to the information on the biological processes and signaling pathways in the GO database, the NCBI Entrez Gene database, and the KEGG pathway database, the roles of the TFs/proteins in the core network biomarkers are projected into three pathways: the SUMOylation, ubiquitination, and proteasome (SUP) pathway; the tumor necrosis factor (TNF) signaling pathway; and the endoplasmic reticulum (ER) signaling pathway.
Network biomarkers of bladder cancer based on a genome-wide genetic and epigenetic network derived from next-generation sequencing data
On the other hand, proteins which regulate the protein modification processes such as folding, sumoylation, ubiquitination and phosphatase activity also displayed significant alteration in the expression level upon intervention with MNQ.
Differential proteomic analysis on the effects of 2-methoxy-1,4-naphthoquinone towards MDA-MB-231 cell line
The SUMOylation is a dynamic and reversible process regulated by both conjugation and de-conjugation enzymes via a three-step process and three enzyme reactions, E1 (SUMO-activation enzyme) (activation), E2 (SUMO conjugation enzyme) (conjugation), and E3 (SUMO ligase) (ligation).
Correlation between E3 SUMO-Protein Ligase NSE2 (NSMCE2) with 5'-nucleotidase, XOR, uric acid and total protein in patients with atherosclerosis
In addition to excitotoxicity and oxidative stress, other neuronal pathways have garnered attention as possible causes of cell death: nitric oxide, intrinsic and extrinsic apoptosis, ubiquitin-proteosome, sumoylation, autophagy, and so on (many of these are reviewed in [34]).
Inductive and deductive approaches to acute cell injury
Inhibition of lung cancer growth by betulinic acid has been attributed to decreases in Sp1 levels via increasing the sumoylation of Sp1 [43].
A review on a mangrove species from the Sunderbans, Bangladesh: Barringtonia racemosa (L.) Roxb
PIASy-mediated Tip60 sumoylation regulates p53-induced autophagy.
Autofagia y respuesta inmunitaria
Further modification events, like sumoylation, regulate the activity of the final transcription factor complex.
Heat shock and the heat shock proteins: an overview

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