sulfotransferase

(redirected from Sulphotransferases)

sul·fo·trans·fer·ase

(sŭl'fō-trans'fĕr-ās),
Generic term for enzymes in EC sub-subclass 2.8.2 catalyzing the transfer of a sulfate group from 3'-phosphoadenylyl sulfate (active sulfate) to the hydroxyl group of an acceptor, producing the sulfated derivative and 3'-phosphoadenosine 5'-phosphate.
Synonym(s): sulfikinase, sulfokinase

sul·fo·trans·fer·ase

(sŭl'fō-trans'fĕr-ās)
Generic term for enzymes in EC sub-subclass 2.8.2 catalyzing the transfer of a sulfate group from 3'-phosphoadenylyl sulfate (active sulfate) to the hydroxyl group of an acceptor.
Synonym(s): sulphotransferase.
References in periodicals archive ?
Glatt, "Toxicity studies with 5-hydroxymethylfurfural and its metabolite 5-sulphooxymethylfurfural in wild-type mice and transgenic mice expressing human sulphotransferases 1A1 and 1A2," Archives of Toxicology, vol.
The results confirmed that silymarin's phenolic compounds undergo extensive metabolism, as do almost all flavonoids, forming sulphate and glucuronide conjugates through the action of UDP-glucuronosyltransferases (UGTs) and sulphotransferases (SULTs) in the small intestine and liver.
The metabolites derived by the action of human UDP-glucuronosyltransferases (UGTs) and sulphotransferases (SULTs) were identified via the loss of the conjugating groups (i.e.
Sulphotransferases. In: Enzyme Systems that Metabolise Drugs and Other Xenobiotics (Ioannides C, ed).
Most importantly one of the most potent effects of phytoestrogens is their ability to inhibit the sulphotransferases. Circulating steroid sulphates are thought to be the major source of estradiol in postmenopausal breast tumours and sulphation is a key step in the activation of some dietary pro-carcinogens (Kirck 2001).