ABCC8

(redirected from Sulfonylurea receptor 1)

ABCC8

A gene on chromosome 11p15.1 that encodes a protein of the MRP subfamily of the superfamily of ATP-binding cassette (ABC) transporters, which transport various molecules across extra- and intracellular membranes, many of which are involved in multidrug resistance. ABCC8 modulates ATP-sensitive K+ channels and insulin release.

Molecular pathology
ABCC8 mutations are linked to hyperinsulinaemic hypoglycaemia of infancy and type-2 diabetes.
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References in periodicals archive ?
Mutations in 6 genes have been associated with HI (Table 1): the sulfonylurea receptor 1 (SUR-1; encoded by ABCC8) [2] (6); potassium inward rectifying channel (Kir6.