pseudoephedrine hydrochloride

(redirected from Sudafed Children's Nasal Decongestant)

pseudoephedrine hydrochloride

Contac Non Drowsy (UK), Galsud (UK), Genaphed, Kidkare Decongestant, Meltus Decongestant (UK), Non-Drowsy Sudafed Decongestant (UK), Robidrine (CA), Silfedrine Children's, Sudafed, Sudafed Children's Nasal Decongestant, Sudafed 12 Hour, Sudo-Tab, Sudodrin, SudoGest

pseudoephedrine sulfate

Drixoral Nasal Decongestant, Drixoral Non-Drowsy Formula

Pharmacologic class: Sympathomimetic

Therapeutic class: Decongestant (systemic)

Pregnancy risk category C

Action

Stimulates alpha-adrenergic receptors, causing vasoconstriction of respiratory tract; relaxes bronchial smooth muscle through beta2-adrenergic stimulation

Availability

pseudoephedrine hydrochloride

Capsules: 60 mg

Capsules (extended-release): 120 mg, 240 mg

Capsules (soft gel): 30 mg

Oral solution: 15 mg/5 ml, 30 mg/5 ml

Syrup: 30 mg/5 ml

Tablets: 30 mg, 60 mg

Tablets (chewable): 15 mg

Tablets (extended-release): 120 mg, 240 mg

pseudoephedrine sulfate

Tablets (extended-release, film-coated): 120 mg

Indications and dosages

Nasal, sinus, or eustachian tube congestion

Adults and children ages 12 and older: 60 mg P.O. q 4 to 6 hours p.r.n. (not to exceed 240 mg/day); or 120 mg (extended-release) q 12 hours or 240 mg (extended-release) q 24 hours

Contraindications

• Hypersensitivity to drug or other sympathomimetics

• Alcohol intolerance (with some liquid products)

• Hypertension

• Severe coronary artery disease

• MAO inhibitor use within past 14 days

• Children younger than age 12 (extended-release forms)

Precautions

Use cautiously in:

• hyperthyroidism, diabetes mellitus, prostatic hypertrophy, ischemic heart disease, glaucoma

• elderly patients (more sensitive to drug's CNS effects)

• pregnant or breastfeeding patients.

Administration

• Give at least 2 hours before bedtime to minimize insomnia.

Adverse reactions

CNS: anxiety, nervousness, dizziness, drowsiness, excitability, fear, hallucinations, headache, insomnia, restlessness, asthenia, seizures

CV: palpitations, hypertension, tachycardia, cardiovascular collapse

GI: anorexia, dry mouth

GU: dysuria

Respiratory: respiratory difficulty

Interactions

Drug-drug. Beta-adrenergic blockers: increased pressor effects of pseudoephedrine

MAO inhibitors: hypertensive crisis

Mecamylamine, methyldopa, reserpine: decreased antihypertensive effect of these drugs

Other sympathomimetics: additive effects, greater risk of toxicity

Drug-food. Foods that acidify urine: decreased drug efficacy

Foods that alkalize urine: increased drug efficacy

Patient monitoring

• Monitor vital signs.

• Assess neurologic and cardiovascular status regularly.

Patient teaching

• Advise patient to take at least 2 hours before bedtime to reduce insomnia.

• Tell patient not to crush or break extended-release tablets or capsules.

• Advise patient to discontinue use and consult prescriber if he experiences nervousness, dizziness, or insomnia.

• Tell patient to consult prescriber before taking other over-the-counter products.

• Caution patient to avoid driving and other hazardous activities until he knows how drug affects concentration and alertness.

• As appropriate, review all other significant and life-threatening adverse reactions and interactions, especially those related to the drugs and foods mentioned above.

pseu·do·e·phed·rine hy·dro·chlor·ide

(sū'dō-e-fed'rin hī'drō-klōr'īd),
The naturally occurring isomer of ephedrine; a sympathomimetic amine with actions and uses similar to those of ephedrine.

pseudoephedrine hydrochloride

(soo″dō-ĕ-fĕd′rĭn)
A sympathomimetic drug, an isomer of ephedrine, that has actions similar to those of ephedrine. Trade names is Sudafed.