Also found in: Dictionary, Thesaurus, Wikipedia.
Related to Sudafed: Sudafed 12 Hour, Sudafed PE


trademark for preparations containing pseudoephedrine hydrochloride, a nasal decongestant.
Miller-Keane Encyclopedia and Dictionary of Medicine, Nursing, and Allied Health, Seventh Edition. © 2003 by Saunders, an imprint of Elsevier, Inc. All rights reserved.

pseudoephedrine hydrochloride

Contac Non Drowsy (UK), Galsud (UK), Genaphed, Kidkare Decongestant, Meltus Decongestant (UK), Non-Drowsy Sudafed Decongestant (UK), Robidrine (CA), Silfedrine Children's, Sudafed, Sudafed Children's Nasal Decongestant, Sudafed 12 Hour, Sudo-Tab, Sudodrin, SudoGest

pseudoephedrine sulfate

Drixoral Nasal Decongestant, Drixoral Non-Drowsy Formula

Pharmacologic class: Sympathomimetic

Therapeutic class: Decongestant (systemic)

Pregnancy risk category C


Stimulates alpha-adrenergic receptors, causing vasoconstriction of respiratory tract; relaxes bronchial smooth muscle through beta2-adrenergic stimulation


pseudoephedrine hydrochloride

Capsules: 60 mg

Capsules (extended-release): 120 mg, 240 mg

Capsules (soft gel): 30 mg

Oral solution: 15 mg/5 ml, 30 mg/5 ml

Syrup: 30 mg/5 ml

Tablets: 30 mg, 60 mg

Tablets (chewable): 15 mg

Tablets (extended-release): 120 mg, 240 mg

pseudoephedrine sulfate

Tablets (extended-release, film-coated): 120 mg

Indications and dosages

Nasal, sinus, or eustachian tube congestion

Adults and children ages 12 and older: 60 mg P.O. q 4 to 6 hours p.r.n. (not to exceed 240 mg/day); or 120 mg (extended-release) q 12 hours or 240 mg (extended-release) q 24 hours


• Hypersensitivity to drug or other sympathomimetics

• Alcohol intolerance (with some liquid products)

• Hypertension

• Severe coronary artery disease

• MAO inhibitor use within past 14 days

• Children younger than age 12 (extended-release forms)


Use cautiously in:

• hyperthyroidism, diabetes mellitus, prostatic hypertrophy, ischemic heart disease, glaucoma

• elderly patients (more sensitive to drug's CNS effects)

• pregnant or breastfeeding patients.


• Give at least 2 hours before bedtime to minimize insomnia.

Adverse reactions

CNS: anxiety, nervousness, dizziness, drowsiness, excitability, fear, hallucinations, headache, insomnia, restlessness, asthenia, seizures

CV: palpitations, hypertension, tachycardia, cardiovascular collapse

GI: anorexia, dry mouth

GU: dysuria

Respiratory: respiratory difficulty


Drug-drug. Beta-adrenergic blockers: increased pressor effects of pseudoephedrine

MAO inhibitors: hypertensive crisis

Mecamylamine, methyldopa, reserpine: decreased antihypertensive effect of these drugs

Other sympathomimetics: additive effects, greater risk of toxicity

Drug-food. Foods that acidify urine: decreased drug efficacy

Foods that alkalize urine: increased drug efficacy

Patient monitoring

• Monitor vital signs.

• Assess neurologic and cardiovascular status regularly.

Patient teaching

• Advise patient to take at least 2 hours before bedtime to reduce insomnia.

• Tell patient not to crush or break extended-release tablets or capsules.

• Advise patient to discontinue use and consult prescriber if he experiences nervousness, dizziness, or insomnia.

• Tell patient to consult prescriber before taking other over-the-counter products.

• Caution patient to avoid driving and other hazardous activities until he knows how drug affects concentration and alertness.

• As appropriate, review all other significant and life-threatening adverse reactions and interactions, especially those related to the drugs and foods mentioned above.

McGraw-Hill Nurse's Drug Handbook, 7th Ed. Copyright © 2013 by The McGraw-Hill Companies, Inc. All rights reserved


A trademark for the hydrochloride salt of the drug pseudoephedrine.
The American Heritage® Medical Dictionary Copyright © 2007, 2004 by Houghton Mifflin Company. Published by Houghton Mifflin Company. All rights reserved.


Collins Dictionary of Medicine © Robert M. Youngson 2004, 2005
References in periodicals archive ?
Names like "Sudafed PE" minimized the change in the active ingredients, relying on well-known brand names to sell the product.
Remedies such as Lemsip powders, Day Nurse and Sudafed should not be sold for under sixes.
pregnancy tests Gillette MACH3, Venus and Sensor razors and refill cartridges Lotrimin Nicorette Oil of Olay Oral B replacement heads Pepcid AC Prilosec Primatene RoC Rogaine Similac Sudafed Schick Quattro razors and all Schick refill cartridges Sonicare replacement heads Tylenol Extra Strength Visine Zantac
Henry Waxman (D-Calif.) has urged the FDA to investigate Pfizer--which was the first company to offer a reformulated alternative to pseudoephedrine, the phenylephrine-based Sudafed PE--for marketing an ineffective medication.
If your stuffy nose or cough doesn't seem to be getting better, add an oral decongestant like pseudoephedrine (Sudafed) and a cough suppressant like dextromethorphan, or DM (Robitussin Cough DM).
It might not have helped that American Novelties owner Johnny Harris told the Arkansas Democrat-Gazette in August that he made most of his money from Sudafed, Tylenol Cold and other pseudoephedrine products rather than his gag gifts.
The subjects were randomly assigned to take either 240 mg of sustained-release pseudoephedrine (Sudafed, Pfizer Inc.) or 10 mg of montelukast (Singulair, Merck & Co.) once daily in the morning at the height of ragweed season.
And Pfizer said it might sell or spin off its consumer healthcare unit, which sells Listerine mouthwash, TCP, Nicorettes and Sudafed.
The law requires prescriptions by mid-2006 for medicines containing pseudoephedrine and two similar substances, used in such popular medicines as Sudafed, Claritin and Theraflu.
The solution to the meth epidemic is not in harsher punishments or mandating prescriptions for Sudafed. It's within each and every addict.
To help with that problem, Pfizer Inc., the maker of Sudafed--an over-the-counter cold medicine containing pseudoephedrine--recently began marketing Sudafed PE, a new version of Sudafed that contains phenylephrine.
As the heart of the cold and flu season arrives in Oregon, consumers are finding they can no longer wander into the store, grab a box of Sudafed and take it to the cashier.