succinate semialdehyde

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suc·ci·nate sem·i·al·de·hyde

(sŭk'si-nāt sem'ē-al'dĕ-hīd),
An intermediate in the catabolism of γ-aminobutyrate.
References in periodicals archive ?
NASDAQ: ALDX) presented novel data at the American Society of Human Genetics 2017 annual meeting demonstrating that ADX-102 reduced levels of gamma-hydroxybutyrate (GHB) and gamma-aminobutyrate (GABA) in a knockout mouse model of Succinic Semialdehyde Dehydrogenase (SSADH) deficiency, the company said.
elata, appeared to irreversibly inactivate the succinic semialdehyde dehydrogenase (SSADH) of bovine brain in in vitro conditions (Table 3, entry 2; Fig.
Emma was diagnosed with the condition Succinic semialdehyde dehydrogenase deficiency at just eight months old in 2011.
In the gastrodin-treated group, both succinic semialdehyde dehydrogenase (SSADH) and succinic semialdehyde reductase (SSAR) immunoreactivities in the hippocampus was also decreased significantly, which stood in contrast to the nontreated group, in which strong SSADH and SSAR immunoreactivities were detected.
Through the GABA shunt, GABA transaminase enzyme catalyzes the conversion of GABA and 2-oxoglutarate into succinic semialdehyde and glutamate, respectively.
GABA is converted to succinic semialdehyde by GABA transaminase.
Jake, who attends Rowan Park special school in Litherland, has suffered with his condition, succinic semialdehyde dehydrogenase deficiency, since he was a toddler.
The scientists discovered that Synechococcus indeed had genes that coded for one important alternative enzyme, succinic semialdehyde dehydrogenase, and that adjacent to the gene for this enzyme was a misidentified gene that subsequently was shown to encode a novel enzyme, 2-oxo-glutarate decarboxylase.
Mary Jane's son, Bart (29), has succinic semialdehyde dehydrogenase deficiency and lives in his own apartment supported by 24-hour caregivers.
GHB is synthesized in brain tissue from GABA by way of a succinic semialdehyde intermediate.
This method uses the enzymes GABA-glutamic transaminase and succinic semialdehyde dehydrogenase to generate spectrophotometrically detectable triphosphopyridine nucleotide (reduced) in direct proportion to the amount of GABA in a sample.
Gail's son, Neal Pergerson 17), has Down syndrome and Mary Jane's son, Bart Sufficool (29), has succinic semialdehyde dehydrogenase deficiency and lives in his own apartment supported by 24-hour caregivers.