Cessation of seizures was defined as the disappearance of EEG seizure activity (all patients with a diagnosis of nonconvulsive status epilepticus underwent continuous EEG monitoring) or the disappearance of previous ictal symptoms without any suspicion of ongoing
subclinical seizure.
In light of these findings, monitoring children with ASDs for seizure and
subclinical seizure activity is recommended.
Inclusion was based upon patients aged 1 to 14 years of age who presented with clinical or
subclinical seizures and belonging to either gender.
Her EEG continued to show right focal SE presenting with both clinical and
subclinical seizures; thus the ketamine infusion rate was increased to 150 mcg/kg/min.
In
subclinical seizures from all patients, no such significant or consistent patterns were observed.
Yet in individual patients, elevated ICP may be associated with cerebral hyperaemia or cerebral ischaemia,
subclinical seizures, or impaired autoregulation (where it is the elevated blood pressure that is the underlying problem).
The finding suggests that physicians "need to consider subtle or
subclinical seizures in the differential diagnosis of cognitive deficits in the elderly," researchers led by Dr.
The question is: can
subclinical seizures, or abnormal brain waves, that are epileptiform (demonstrating spikes or sharp waves which signify an increased risk of developing seizures) account for some of the symptoms in autism such as language dysfunction?
In another case report, a patient with post-traumatic seizures had paroxysmal rise in ICP with
subclinical seizures (10).
Children who are not achieving their expected potential should have: a thorough evaluation for remediable causes including an evaluation of possible
subclinical seizures (seizures that may not be recognized by those around them); an evaluation of possible medication effects; neuropsychological testing to determine any specific impairments as well as specific strengths the child may have; and an assessment of any social factors that may be interfering with academic achievement.
