drug holiday

(redirected from Structured treatment interruptions)
Also found in: Dictionary.

drug hol·i·day

(drŭg hol'i-dā),
Interval of time when a chronically medicated patient temporarily stops taking the medication; used to allow some recuperation of normal functions, to maintain sensitivity to the drug, and to reduce the likelihood of side-effects.

drug holiday

n.
A usually brief period during which a drug that is typically taken on a daily basis, such as an antidepressant, is not taken or is replaced with another in order to minimize certain side effects.

drug holiday

a period of drug withdrawal to reverse ineffectiveness of a drug resulting from receptor desensitization or adverse effects that may result from chronic treatment. For example, after a 7- to 10-day drug holiday, levodopa responsiveness appears to be enhanced, and lower doses are required to produce a therapeutic effect.
Therapeutics A time frame during which a drug is proscribed, to evaluate baseline behaviour or decreased the dose of psychoactive drugs, and possibly the incidence of tardive dyskinesia
Vox populi A trip to a place where some usually illicit drugs are legal—e.g., Amsterdam, Jamaica

drug holiday

Psychiatry A period in which a prescribed drug is proscribed, to evaluate baseline behavior or ↓ the dose of psychoactive drugs, and possibly incidence of tardive dyskinesia. See Tardive dyskinesia.

drug hol·i·day

(drŭg hol'i-dā)
Interval when a patient on long-term medication temporarily stops taking the prescribed medication; used to allow some recuperation of normal functions or to maintain sensitivity to the drug(s).

drug hol·i·day

(drŭg hol'i-dā)
Interval of time when a patient on long-term medication temporarily stops taking the medication; used to allow some recuperation of normal functions.
References in periodicals archive ?
Although CHER and BANA II probably cannot by themselves determine whether structured treatment interruptions will work better--and be safer--in children than in adults, they may at least help HIV pediatricians decide whether to pursue study of this strategy.
A prospective trial of structured treatment interruptions in human immunodeficiency virus infection.
Although the trial found that patients in the structured treatment interruption arm had more serious adverse events, the interruptions were terminated once this was determined and all patients were put on continuous therapy.
I think we can safely predict that structured treatment interruptions will induce remission in only a small number of patients," Hirschel says.
This challenges the idea that repeated cycles of structured treatment interruptions are critical to immune control of the virus.
Patients will also undergo structured treatment interruptions following immunization, and will be followed for a minimum of three years.
Another strategy with reported early success was Structured Treatment Interruptions (STIs).
Prior to this study, some scientists had believed that structured treatment interruptions could eliminate existing resistance.
Drug resistance persists despite structured treatment interruptions (STIs), according to a presentation by Dr.
She was the driving force behind the Coalition for Salvage Therapy, pushing for faster access to new antiretroviral agents, and the Structured Treatment Interruptions Workshops, which brought together leading researchers to figure out if these stops and starts in therapy could have some benefit, or at least do no harm.
Exposure to sufficient titers of autologous virus has been the idea behind using structured treatment interruptions (STIs) in clinical research.

Full browser ?