matrix metalloproteinase 3

(redirected from Stromelysin-1)

matrix metalloproteinase 3

An enzyme encoded on chromosome 11q22.3 which degrades various tissue substrates (e.g., collagens and others).

Cytokine inducers
EGF, CD40L, EGF, FGF-a, FGF-b, FGF-7, FGF-9, GM-CSF, HGF, hourG-β1, IFN-β, IFN-γ, IL-1α, IL-1β, IL-4, IL-5, IL-6, sIL-6 Rα, IL-8, IL-10, MIF, oncostatin M, PD-ECGF, PDGF, PDGF-AA, PDGF-BB, PF4, TGF-α, TGF-β1, TNF-α, TNF-β, VEGF.
 
Substrates
Collagens III, IV, V and IX; gelatin; aggrecan; versican and hyaluronidase-treated versican; perlecan; decorin; proteoglycan link protein; large tenascin-C; fibronectin; laminin; entactin; osteonectin; elastin; casein; α1-AT, α1-ACHYM; antithrombin-III; α2M; ovostatin; Substance P; MBP; GST-TNF/TNF peptide; IL-1β; serum amyloid A; IGF-binding protein-3; fibrinogen and cross-linked fibrin; plasminogen; MMP-1 “superactivation”; MMP-2/TIMP-2 complex; MMP-7; MMP-87; MMP-9; MMP-1.
References in periodicals archive ?
Matrix metalloproteinase stromelysin-1 triggers a cascade of molecular alterations that leads to stable epithelial-to-mesenchymal conversion and a premalignant phenotype in mammary epithelial cells.
Also, dermal matrix metalloproteinases upregulation stimulates the production of collagenase, gelatinase and stromelysin-1 in both fibroblasts and keratinocytes, resulting in a deterioration of both collagen and elastin, as well as of other components of the dermal extracellular matrix.
Collagenases, gelatinases, stromelysin-3, matrilysin, MT1-MMP [99], and stromelysin-1 [100] are considered the most closely associated to the invasive phenotype.
Fucoidan prevents inflammation by inhibiting gelatinase A secretion and stimulating stromelysin-1 induction (90).
Inmunohistochemical study of neutrophil and fibroblast type collagenases and stromelysin-1 in adult periodontitis.
A longitudinal study of cartilage matrix metabolism in patients with cruciate ligament rupture: Synovial fluid concentrations of aggrecan fragments, stromelysin-1 and tissue inhibitor of metalloproteinase-1.
Carotid intima-media thickness is associated with allelic variants of stromelysin-1, interleukin-6 and hepatic lipase genes.
UV irradiation triggered initial events and in subsequent signaling resulting in enhanced expression of two major members of the matrix metalloproteinase family, the interstitial collagenase (MMP-1) and stromelysin-1 (MMP-3), in human dermal fibroblasts (Brenneisen et al.
Increased levels of stromelysin-1 and tissue inhibitor of metalloproteinases-1 in sera from patients with rheumatoid arthritis.
The 5A/6A polymorphism of the stromelysin-1 gene and restenosis after percutaneous coronary interventions.
Stromelysin-1 and interleukin-6 gene promoter polymorphism are determinants of asymptomatic carotid artery atherosclerosis.
The matrix metalloproteinase stromelysin-1 acts as a natural mammary tumor promoter.