CXCL12

(redirected from Stromal cell-derived factor 1)
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CXCL12

A gene on chromosome 10q11.1 that encodes a stromal cell-derived alpha chemokine of the intercrine family which, once bound to its receptor, CXCR4, activates lymphocytes, an interaction that has been implicated in the metastasis of breast and other cancers.

Molecular pathology
CXCL12 mutations are associated with resistance to HIV-1 infections.
References in periodicals archive ?
Liakouli et al., "Differential expression of stromal cell-derived factor 1 and its receptor CXCR4 in the skin and endothelial cells of systemic sclerosis patients: Pathogenetic implications," Arthritis and Rheumatism, vol.
Stumm et al., "Overexpression of stromal cell-derived factor 1 and its receptor CXCR4 induces autocrine/paracrine cell proliferation in human pituitary adenomas," Clinical Cancer Research, vol.
JVS-100 induces the production of Stromal cell-Derived Factor 1 (SDF-1), a chemokine important in the body's natural tissue repair process.
Stromal cell-derived factor 1 regulates primitive hematopoiesis by suppressing apoptosis and by promoting G0/G1 transition in [CD34.sup.+] cells: evidence for an autocrine/paracrine mechanism.
JVS-100 encodes Stromal cell-Derived Factor 1 (SDF-1), which has been shown to repair damaged tissue through recruitment of circulating stem cells to the site of injury, prevention of ongoing cell death and restoration of blood flow.
Chen, "Stimulation of matrix metalloprotease 3 release from human chondrocytes by the interaction of stromal cell-derived factor 1 and CXC chemokine receptor 4," Arthritis & Rheumatism, vol.
Muller, "Concise review: the potential of stromal cell-derived factor 1 and its receptors to promote stem cell functions in spinal cord repair," Stem Cells Translational Medicine, vol.
The Flt-3 ligand (FLT3LG), interleukin-6 (IL-6), and thrombopoietin (TPO) influence HSC proliferation, differentiation, and self-renewal, while stromal cell-derived factor 1 (SDF-1) reduces the production of inflammatory cytokines and chemokines [58-61].