Trichostatin produced from Streptomyces hygroscopicus
is a well-known Histone deacetylase (HDAC) inhibitor, a validated target for the development of antitumor therapies (9).
also observed an inhibition effect of phosphate on biosynthesis of turimycin, the secondary metabolite of Streptomyces hygroscopicus
 reported that a 2.8-fold increase of antifungal production by Streptomyces hygroscopicus
BS-112z could be accomplished by using the RSM approach.
Similarly, a higher agitation speed resulted in decreased DCW gain but increased antibiotic production by Streptomyces clavuligerus, Streptomyces hygroscopicus
, Enterobacter cloacae, and Bacillus thuringiensis.
Sirolimus (also known as rapamycin) is a macrocylic lactone immunosuppressive agent produced by Streptomyces hygroscopicus
. It inhibits T-lymphocyte activation and proliferation due to antigen and cytokine stimulation, and reduces antibody production.
Rapamycin, an antifungal, anticancer, and immune-suppressing compound secreted by the bacterium Streptomyces hygroscopicus
, is the basis for an anti-aging drug being developed by the Swiss pharmaceutical company Novartis.
.Lipid and fatty acid composition of cytoplasmic membranes from Streptomyces hygroscopicus
and its stable protoplast-type L form.
Sirolimus is a macrolide-group antibiotic that is isolated from Streptomyces hygroscopicus
[27.] Igarashi Y, T Iida R, Yoshida and T Furumai Pteridic acids A and B, novel plant growth promoters with auxin-like activity from Streptomyces hygroscopicus
The alpha glucosidase inhibitors (AGIs) were initially isolated from bacterial cultures or their derivatives: acarbose from Actinoplanes, miglitol, a semisynthetic derivative of 1-deoxynojirimycin, from Bacillus and Streptomyces sp.,and voglibose, from validamycin A, a product of Streptomyces hygroscopicus
Rapamycin was early discovered in 1975 as an antifungal agent produced by Streptomyces hygroscopicus
and has a great potency against Candida albicans (Vezina et al., 1975).
Weiss et al, "Mannopeptimycins, new cyclic glycopeptide antibiotics produced by Streptomyces hygroscopicus
LL-AC98: antibacterial and mechanistic activities," Antimicrobial Agents and Chemotherapy, vol.