KLK7

(redirected from Stratum corneum chymotryptic enzyme)

KLK7

A gene on chromosome 19q13.3 that encodes a serine protease that catalyses the degradation of intercellular cohesive structures in the cornified layer of the skin during the normal shedding of cells from the skin surface. KLK7 may play a role in activating precursors of inflammatory cytokines.
References in periodicals archive ?
hK7, also known as human stratum corneum chymotryptic enzyme, was first identified in human skin extracts (15).
Unfavorable prognostic value of human kallikrein 7 quantified by ELISA in ovarian cancer cytosols
Human stratum corneum chymotryptic enzyme (hK7; HSCCE) (9,10), one of the few tissue kallikreins for which a physiologic function has been proposed, catalyzes the degradation of intercellular cohesive structures in the outermost layer of the skin and contributes to the cell shedding process at the skin surface (11).
The KLK7 (PRSS6) gene, encoding for the stratum corneum chymotryptic enzyme is a new member of the human kallikrein gene family-genomic characterization, mapping, tissue expression, and hormonal regulation.
The stratum corneum chymotryptic enzyme that mediates shedding and desquamation of skin cells is highly overexpressed in ovarian tumor cells.
Quantitative reverse transcription-PCR assay for detection of mRNA encoding full-length human tissue kallikrein 7: prognostic relevance of KLK7 mRNA expression in breast cancer
Human stratum corneum chymotryptic enzyme (HSCCE) [4] is a chymotrypsin-like serine protease that was first identified in human skin extracts (1) and Alzheimer disease brain (US Patent 6,093,397).
Immunolocalization of stratum corneum chymotryptic enzyme in human skin and oral epithelium with monoclonal antibodies: evidence of a proteinase specifically expressed in keratinizing squamous epithelia.
Cloning, expression, and characterization of stratum corneum chymotryptic enzyme.
Development of an immunofluorometric assay and quantification of human kallilkrein 7 in tissue extracts and biological fluids
The KLK7 (PRSS6) gene, encoding for the stratum corneum chymotryptic enzyme is a new member of the human kallikrein gene family--genomic characterization, mapping, tissue expression and hormonal regulation.
Human tissue kallikreins: a family of new cancer biomarkers
Two additional kallikrein genes, KLKS (also known as neuropsin or TADG-14) (18) and the gene that encodes stratum corneum chymotryptic enzyme (19,20) are upregulated in ovarian cancer.
Human kallikrein gene 5 (KLK5) expression by quantitative PCR: an independent indicator of poor prognosis in breast cancer
The role that pro- and stratum corneum chymotryptic enzymes (SCCE) play in desquamation was the topic of the next speaker's presentation.
IFSCC Meets in Berlin
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