SFN

(redirected from Stratifin)
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SFN

A gene on chromosome 8q23.1 that encodes an adapter protein which regulates a broad spectrum of general and specialised signalling pathways by binding to a large number of partners, usually by recognising a phosphoserine or phosphothreonine motif. When bound to KRT17, stratifin regulates protein synthesis and epithelial cell growth by stimulating the AKT/MTOR pathway. It is a p53-regulated inhibitor of G2/M progression.
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Increased expression of epidermal fatty acid binding protein, cofilin, and 14-3-3-sigma (stratifin) detected by two-dimensional gel electrophoresis, mass spectrometry and microsequencing of drug-resistant human adenocarcinoma of the pancreas.
(11) analyzed the proteome of 150 bladder tumors and observed a decline in the expression of specific cytokeratins, psoriasin, galectin 7, and stratifin in tumors with a low degree of differentiation.