Storiform Pattern

A pattern seen by low-power light microscopy, which is characterised by loosely-arranged whorls of elongated, spindled fibroblast-like cells. The highly nonspecific storiform pattern is often seen in fibrohistiocytic lesions. It may be benign—e.g., dermatofibroma, giant cell tumour of tendon sheath—of low malignant potential—e.g., atypical fibroxanthoma, dermatofibrosarcoma protuberans—or malignant—e,g, fibrosarcoma; it may also be seen in non-histiocytic lesions—e.g., nodular fascitis, leiomyoma, leiomyosarcoma, Schwann cell tumours, spindle cell carcinoma
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Nonossifying fibroma contains fascicles of spindle cells arranged in a storiform pattern; however, the neoplastic cells lack the deeply eosinophilic cytoplasm and rhabdomyoblast-like cells characteristic of PH.
[1] Histologically, DFSP is characterised by a fibroblastic proliferation of tumour cells arranged around a central storiform pattern. [2] DFSP tumour cells exhibit a chromosomal translocation of genes COL1A9 and PGDF p (t17, 22) which encode to alpha chain of type I collagen and beta chain of platelet derived growth factors.
The tumour cells are composed of uniform population of monomorphic spindle cells arranged in storiform pattern with mitotic figures not exceeding 5 per 10 HPF.13 The American Joint Committee on Cancer has not established a staging system for Dermatofibrosarcoma Protuberans (DFSP).
Final pathological examination showed a tumour composed of malignant spindle cells (figure 2 and 3; spindle shaped cells are arranged in storiform pattern) that are CD 34 positive (Figure 4; diffuse expression of CD34) and CK, S100, ER, PR and CD 68 negative which suggest the diagnosis of low-grade dermatofibrosarcoma protuberans.
Sclerotic fibroma of the skin is a benign fibrous tumor, often situated in the reticular dermis.[17] It is usually solitary and has relative hypocellularity with a prominent feature that thick collagen bundles are arranged in a storiform pattern. The maximum diameter is <1 cm.[18] Low-grade fibromyxoid sarcoma is more cellular, has alternating fibrous and myxoid zones and characteristic whorled growth pattern.[19]
Extraction and culturing of cells from some tumors exhibited a storiform pattern which contained pleomorphic and giant cells with phagocytosis-like movements, these features seemed reminiscent of histiocytes.
Microscopically, tumor was composed of ovoid to spindle-shaped cells arranged in sheets and focal storiform pattern (Figure 5(a)).
The histological specimen showed a storiform pattern with giant cells (Figure 7(a)).
In this case, the mesenchymal elements composed of fibrosarcomatous malignant cells characterized by undifferentiated anaplastic spindle cells resembled mature fibroblast in a storiform pattern and the immunohistochemical analysis.
The author reported that in a group of nine cutaneous tumours, characterized by indolent growth and a prominent storiform pattern, four cases showed melanin pigment.
The submucosal region had a circumscribed nodule with proliferation of loosely cohesive spindle cells; some of which were arranged in vague storiform pattern and others in long fascicles.
The cellular fibrostroma consists of plump fibroblastic spindle cells arranged in fascicular to storiform pattern with basophilic nuclei.