storage lesion

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storage lesion

Transfusion medicine The constellation of changes occurring in a unit of packed red cells during storage. See Red cell preservatives.
Storage lesions
Ammonium to 470 µmol/L–US: 800 µg/dL
Free Hb in plasma from 82 to 6580 mg/L–US: 8.2 to 658 mg/dL
K+ from 4.2 to 78.5 mmol/L–US: 4.2 to 78.5 mEq/L
ATP from 100% to 45%
2,3 DPG to < 10% of original levels–replenished within 24 hours of transfusion
Labile proteins, eg complement, fibronectin and coagulation factors ↓ to negligible
Na+ from 169 to 111 mmol/L–US: 169 to 111 mEq/L
pH from 7.6 to 6.7
Adverse physiologic effects of stored blood is negligible in the absence of a previous compromise of the Pt's–recipient's status
McGraw-Hill Concise Dictionary of Modern Medicine. © 2002 by The McGraw-Hill Companies, Inc.

storage lesion

In blood banking and transfusion therapy, the biochemical and structural degradation of blood cells that occurs over time.
See also: lesion
Medical Dictionary, © 2009 Farlex and Partners
References in periodicals archive ?
These polysaccharides, called glycosaminoglycans, accumulate in tissues of MPS I patients, resulting in characteristic storage lesions and diverse clinical signs and symptoms including in the CNS.
MPS I is a rare autosomal recessive genetic disease caused by deficiency of IDUA, an enzyme required for the breakdown of the polysaccharides,which accumulate in tissues of MPS I patients, resulting in characteristic storage lesions and diverse clinical signs and symptoms including in the CNS, which can include excessive accumulation of fluid in the brain, spinal cord compression and cognitive impairment, said the company.
Many morphological, biochemical and functional changes occur during this storage period of platelets, which are termed as platelet storage lesions. These lesions are important because they can affect post-transfusion survival of cells.7
During the ex vivo storage, RBC experienced biochemical, structural, and functional alternations, which are collectively referred to "storage lesion." Despite the well-investigated, apparent, and documented storage lesions, the clinical significance of transfusing the stored RBC remains unclear.
Results: The ex vivo changes to RBC that occur during storage are collectively called storage lesion. It is still inconclusive if transfusion of RBC with storage lesion has clinical relevance.
These biochemical, structural, and functional alternations are collectively referred to "storage lesion".
Although blood storage is an important evolution in the field of transfusion, stored red blood cells undergo a series of changes known as storage lesions, which tend to become worse with the passage of time [3].
These storage lesions are indicative of loss of quality of the stored blood, which may contribute towards occurrences of post-transfusion reactions [5, 6].
D'Almeida, "The red cell storage lesion and its implication for transfusion," Transfusion and Apheresis Science, vol.
There are recent concerns about the benefit of blood transfusions to critically ill patients due to immunomodulation and storage lesions found in banked blood.
Storage lesions include RBC rheology, the loss of shape, and flexibility, (12) the decrease in the concentration of molecular modulators of oxygen binding (e.g., 2,3-DPG), the decrease in nitricoxide bioactivity, and the increase in RBC adhesiveness during prolonged storage.
They also noted a deficiency in vasodilotary activity in banked blood when compared with "fresh blood." Banked blood used for transfusion still has some shortcomings, but researchers are now contemplating reducing some of the storage lesions by replenishing nitrosylation in banked blood before using it for transfusion.