fibrodysplasia ossificans progressiva

(redirected from Stone man syndrome)

fibrodysplasia ossificans progressiva (FOP)

 
A rare genetic disease characterized by acute soft-tissue swelling after minor trauma, such as dental work or intramuscular injections, that leads to heterotopic bone formation.
Miller-Keane Encyclopedia and Dictionary of Medicine, Nursing, and Allied Health, Seventh Edition. © 2003 by Saunders, an imprint of Elsevier, Inc. All rights reserved.

fi·bro·dys·pla·si·a os·sif·'i·cans pro·gres·si·'va

[MIM*135100]
a generalized disorder of connective tissue in which there is ectopic ossification with bone replacing tendons, fasciae, and ligaments; a lethal genetic disorder of autosomal dominant inheritance.
See also: fibrous dysplasia of bone.
Farlex Partner Medical Dictionary © Farlex 2012
A rare idiopathic or autosomal dominant MIM 135100 condition of irregular penetration and pre-pubertal onset, in which connective/interstitial tissues undergo extensive fibrosis and heterotopic ossification of ligaments, tendons, muscle, fascia, aponeuroses and skin, first seen in late childhood as firm masses. The abnormal development of bone may lead to stiffness in affected areas and may also limit movement in affected joints, e.g., knees, wrists, shoulders, spine, and/or neck
DiffDx Osseous metaplasia, myositis ossificans, extraskeletal osteosarcoma
Segen's Medical Dictionary. © 2012 Farlex, Inc. All rights reserved.

fibrodysplasia ossificans progressiva

FOP, Generalized myositis ossificans, myositis ossificans progressiva, stone man An idiopathic or AD condition of irregular penetration and pre-pubertal onset, in which connective/interstitial tissues undergo extensive fibrosis and heterotopic ossification of ligaments, tendons, muscle, fascia, aponeuroses, skin, first seen in late childhood as firm masses Clinical Microdactyly, focal, transient, ±painful ossifying tumors in neck, back and extremities, with bony replacement of fasciae, ligaments and fibrotendinous tissue; also baldness, deafness, mental retardation, fever; tragically, Pts may find jobs in circus 'freak' shows; usually glossal, diaphragmatic, laryngeal, and perineal muscles are spared and Pts die of respiratory infections as intercostal muscles become petrified DiffDx Osseous metaplasia, myositis ossificans, extraskeletal osteosarcoma. Cf Parana hard skin syndrome, Stiff man syndrome.
McGraw-Hill Concise Dictionary of Modern Medicine. © 2002 by The McGraw-Hill Companies, Inc.
References in periodicals archive ?
A schoolboy has been diagnosed with a deadly one-in-two-million condition called "stone man syndrome" that is causing him to grow a second skeleton.
Millie is one of just 40 people in the UK and 700 across the globe with fibrodysplasia ossificans progressiva, or stone man syndrome. Sufferers aren't expected to live past 40 and there is no cure, although experts are working to discover one.
For five years she has been battling fibrodysplasia ossificans progressiva, known as FOP or stone man syndrome. It turns muscles, ligaments and tendons into solid bone.
The topper, though, was "stone man syndrome", or fibrodysplasia ossificans progressiva.
lewis.panther@people.co.uk | To donate to Sinead's Kilimanjaro climb, go to uk.virginmoneygiving.com/team/climbingforacure Stone man syndrome FOP (fibrodysplasia ossificans progressiva) is some-times called stone man syndrome and is a genetic mutation of the body's repair mechanism.