stiff-person syndrome

stiff-person syndrome

(stĭf′pûr′sən)
n.
An adult-onset neurological disorder characterized by muscle spasms and progressive muscle stiffness.

stiff-per·son syn·drome

(stif'pĕr-sŏn sin'drōm)
A rare disorder manifested clinically by the continuous isometric contraction of many of the somatic muscles; contractions are usually forceful and painful and most frequently involve the trunk musculature, although limb muscles may be involved. This is an autoimmune disease, with circulating antibodies against the GABA-synthesizing enzyme and glutamic acid decarboxylase, among other types of antibodies present.
References in periodicals archive ?
We had nine patients with PNS; two patients had subacute cerebellar degeneration (SCD); three had Stiff-person syndrome (SPS); one had Lambert-Eaton myasthenic syndrome (LEMS); and the remaining patient had sensory neuropathy (SN).
Mackay, "Stiff-person syndrome (SPS) and anti-GAD-related CNS degenerations: protean additions to the autoimmune central neuropathies," Journal of Autoimmunity, vol.
I'm like a bodybuilder." Stiff-Person Syndrome afflicts twice as many women as men and is often misdiagnosed as a range of conditions, including Parkinson's disease and multiple sclerosis.
The clinical spectrum of anti- GAD antibody-positive patients with stiff-person syndrome. Neurology 2000; 55:1531-1535.
Stiff-person syndrome associated with oral isotretinoin treatment.
They discuss the pretherapeutic history of botulinum neurotoxin, the history of its clinical development, its pharmacology and immunological properties, and treatments for cervical dystonia, blepharospasm, oromandibular dystonia, laryngeal muscle hyperactivity syndromes, otorhinolaryngological conditions, hemifacial spasm, spasticity, spastic infantile cerebral palsy, tic disorders, essential hand and head tremor, stiff-person syndrome, ophthalmological applications, cosmetic uses, hyperhidrosis, ischemic digits, neuropathic pain, headaches, musculoskeletal pain and arthritis, plantar fasciitis, low-back pain, piriformis syndrome, the gastrointestinal tract, and urological disorders.
The stiff-person syndrome: An autoimmune disorder affecting neurotransmission of gamma-aminobutyric acid.
Central nervous system Limbic encephalitis Encephalomyelitis Brainstem encephalitis Stiff-person syndrome Opsoclonus-myoclonus Subacute cerebellar degeneration Paraneoplastic visual syndromes Cancer-associated retinopathy Melanoma-associated retinopathy Paraneoplastic optic neuropathy Motor neuron syndromes Subacute motor neuronopathy Other motor neuron syndromes Peripheral nervous system Acute sensorimotor neuropathy Subacute sensory neuronopathy Chronic sensorimotor neuropathy Subacute autonomic neuropathy Paraneoplastic peripheral nerve vasculitis Neuromuscular junction and muscle Myasthenia gravis Lambert-Eaton syndrome Polymyositis/dermatomyositis Acute necrotizing myopathy Cachectic myopathy Neuromyotonia TABLE 2: Diagnostic criteria of paraneoplastic limbic encephalitis.
Her one-in-a-million disorder - called stiff-person syndrome - leaves her body frozen and an attack could be fatal.