The previous decade has seen considerable research in this field and the findings have shown that, in addition to aromatase (AROM), another enzyme, steroid sulfatase (STS), has a critical role in oestrogen biosynthesis in breast cancer.
Development of steroid sulfatase (STS) inhibitors In the light of increasing evidence from earlier studies, the search for STS inhibitors began in the late 1980s and the early 1990s.
Steroid sulfatase inhibitors: Promising new tools for breast cancer therapy?
Steroid sulfatase inhibitors for oestrogen- and androgen-dependent cancers.
Oestrogen Sulfotransferase and Steroid Sulfatase in Human Breast Carcinoma.
Irosustat: a first-generation steroid sulfatase inhibitor in breast cancer.
A novel steroidal selective steroid sulfatase inhibitor KW-2581 inhibits sulfated-oestrogen dependent growth of breast cancer cells in vitro and in animal models.
Inhibition of steroid sulfatase activity and cell proliferation in ZR-75-1 and BT-474 human breast cancer cells by KW-2581 in vitro and in vivo.
Novel D-ring modified steroid derivatives as potent, non- oestrogenic, steroid sulfatase inhibitors with in vivo activity.