STK25

(redirected from Ste20-like kinase)

STK25

A gene on chromosome 2q37.3 that encodes a ubiquitously expressed serine/threonine-protein kinase activated in response to oxidant stress, which thus may play a role in the response to environmental stress. It is phosphorylated upon DNA damage, probably by ATM or ATR, and targets to the Golgi apparatus where it is thought to regulate protein transport, cell adhesion and polarity complexes, which are important for cell migration.
References in periodicals archive ?
Interestingly, chronic [beta]1-AR stimulation by transgenic expression of [beta]1-AR or by isoproterenol injection also resulted in necrotic myocyte death that is dependent on mammalian Ste20-like kinase 1 (Mst1) [151].
AC, adenylyl cyclase; CaMKII, [Ca.sup.2+]/CaM-dependent kinase II; cAMP, cyclic adenosine monophosphate; Cyt c, cytochrome c; DAG, diacylglycerol; E2F1, E2F transcription factor 1; ECM, extracellular matrix; ERK, extracellular signal-regulated kinase; FADD, Fas-associated death domain; FAK, focal adhesion kinase; GPCR, G protein-coupled receptor; IP3, inositol 1,4,5-trisphosphate; MEK1, mitogen-activated protein kinase 1; Mst1, mammalian Ste20-like kinase 1; NICD, Notch intracellular domain; PI3K, phosphoinositide 3-kinase; PIP2, phosphatidylinositol bisphosphate; PIP3, phosphatidylinositol trisphosphate; PLC[beta], phospholipase C PKA, cyclic AMP-dependent protein kinase; PKC, protein kinase C; RTK, receptor tyrosine kinase.
Draves et al., "Caspase-mediated activation and induction of apoptosis by the mammalian Ste20-like kinase Mst1," The EMBO Journal, vol.