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Related to statins: pravastatin, Lipitor

re·leas·ing fac·tors (RF),

1. any substance, usually of hypothalamic origin, capable of accelerating the rate of secretion of a given hormone by the anterior pituitary gland;
2. factors required in the termination phase of either RNA biosynthesis or protein biosynthesis. Synonym(s): termination factor
3. colloquial shortened form for the HMG-CoA reductase inhibitors used as antihyperlipidemic agents, whose generic names end with the suffix statin. Synonym(s): statins


Drugs of the hydroxymethyl glutaryl coenzyme A reductase inhibitor class (HMG-CoA reductase inhibitors). These drugs block the liver's production of cholesterol by competitive inhibition of the reductase coenzyme that catalyzes the rate-limiting step of cholesterol synthesis. They can lower the levels of low-density lipoproteins (LDLs) by 25–45 per cent and a number of major trials have shown their benefits in preventing heart attacks and other effects of ATHEROSCLEROSIS. They reduce the risk of sepsis and fatal sepsis in people with cardiovascular disease, and it has been established that intensive statin treatment after heart attacks provides greater protection against death than does a standard regimen. Recent research on mice has suggested that statins may have some value in MULTIPLE SCLEROSIS because of an effect of diminishing the cellular immune reponse. This growing drug class includes atorvastatin (Lipitor), cerivastatin (Liponay), fluvastatin (Lescol), pravastatin (Lipostat), rosuvastatin (Crestor) and simvastatin (Zocor). Note that the root ‘statin’ has proved popular with pharmacological neologists so, unfortunately, there are many other drugs, not in the HMG-CoA reductase inhibitor class, with ‘statin’ in their names.


A class of drugs commonly used to lower LDL cholesterol levels.
Mentioned in: C-Reactive Protein

Patient discussion about statins

Q. husband has horrible rash bil. below knees to his ankles. it is bright red yellow weeping cracks. On statins He has been on zocor for 15 years and we are so afraid this may have something to do with this drug. He has stopped taking the drug because the pain and weakness, and numbness in his legs is considerable

A. i looked up for side effects and i saw only "eczema" as a skin side effect. but it seems odd to me that after 15 years you got this kind of side effect. it should have appeared years ago. you know- it might be a very good idea to go and see a Dr... and not stopping a medication without warning..

More discussions about statins
References in periodicals archive ?
Under the Taiwanese health system, doctors have to stop prescribing statins once a patient's cholesterol falls to its target level.
A total of 2 067 639 patients aged 40 years or older and newly treated with statins between 1 January 1997 and 30 April 2008 participated.
About half of your cholesterol is actually made in your liver (not from your diet) and statins directly stop that process.
In the unmatched cohort, we found mortality rates of 96 (86-106) per 1,000 [patient-years] for patients in therapy with statins and 121 (117-125) for the nonstatin patients and a [hazard ratio] of 0.
Some previous research has suggested that statins, used to treat high cholesterol, may protect against Parkinson's disease.
Experts and charities are now calling for a randomised clinical trial to test the effect of statins by comparing two groups of patients.
He continued: Statins have other beneficial, non-cholesterol lowering, effects.
Studies show that some statins, such as rosuvastatin (Crestor[R]), are associated with a 27% increased risk of developing new-onset type II diabetes.
NEW ORLEANS--High-intensity statin therapy in patients with peripheral artery disease was associated with significant reductions in amputations as well as mortality during up to 5 years of follow-up in the first large study to examine the relationship, Shipra Arya, MD, reported at the American Heart Association scientific sessions.
Julie Zissimopoulos of the Schaeffer Center for Health Policy and Economics, and colleagues examined the Medicare records of nearly 400,000 statins users from 2006 to 2013.
But even if one's cholesterol levels are within normal range, there is now convincing data that taking statins regularly can benefit our relatively senior adults, regardless of whether they have heart disease or not, and regardless of their cholesterol levels.