The pathway we discovered is part of a conserved starvation response
that actually makes nutritious food taste better when you are starving," said Associate Professor Neely.
This research, aimed at reducing the starvation response
by alternating periods of weight reduction/maintenance (intermittent dieting), found promising results.
They broke down the starvation response
in the fruit flies into separate mechanisms for hunger and sleep-suppression.
The observed atrophy of the digestive tubules in the control oysters is likely a starvation response
concurrent with increased temperature.
If the body experiences prolonged periods of less food consumption than it needs, a starvation response
is triggered that prompts the body to become extremely conservative in energy expenditure.
Dr Longo's team was interested to know if the starvation response
differed between normal and cancer cells.
"Your body is going into a starvation response
, it's pushing you to over-eat because it's saying 'I don't know when the next meal is coming, I better eat now'.
It is known, for example, that sudden calorie-restriction dieting produces what is called the "Starvation Response
." That is, the resting metabolic rate (RMR) drops as the body experiences something akin to what happened millennia ago when the hunt failed and in order to improve its chances for survival the body would drop its RMR over a relatively long period of time.
The problem with missing meals is that it triggers a starvation response
"We found the tumor suppressor Rb is a critical regulator of the starvation response
," said Han, who also is a Howard Hughes Medical Investigator.
This mimics a clinical feature of diabetic patients resulting from the fact that nutrients are present but the body cannot utilize them and thus mounts a starvation response
, breaking down energy stores to obtain nutrients.
Poirier, "Regulation of phosphate starvation responses
in plants: signaling players and cross-talks," Molecular Plant, vol.