is the most common form of juvenile macular degeneration with an incidence of approximately 1 in 10,000 births.
is a form of macular degeneration that causes disabling loss of sight in young people.
New ABCR mutations and clinical phenotype in Italian patients with Stargardt disease
Both proliferative diabetic retinopathy and Stargardt disease
are two very serious retinal diseases.
The grant will include support for identifying new retinal-disease genes--including those causing conditions such as retinitis pigmentosa and age-related macular degeneration-through the use of next-generation genetic discovery technologies; developing a better understanding of retinal ciliopathies; and enhancing retinal imaging technologies to select and follow patients for future Leber congenital amaurosis (CEP290 mutations) and Stargardt disease
gene therapy clinical trials.
Professor James Bainbridge, who will head the trial, which was given the green light by the Medicines and Healthcare Products Regulatory Agency, said: "There is real potential that people with blinding disorders of the retina, including Stargardt disease
and age-related macular degeneration, might benefit in the future from transplantation of retinal cells.
Once the complication issues are addressed, we believe this technique could become a new therapeutic approach for not only retinitis pigmentosa, but age-related macular degeneration, Stargardt disease
, and other forms of retinal disease that also feature loss of retinal cells," said Tsang.
In experimental studies, such as a detailed evaluation of the transition zones between more diseased and less diseased retinal areas in Stargardt disease
, a one-dimensional pattern extending along one meridian may be an appropriate option, in order to balance the benefit of high spatial density pattern with the potential fatigue of a lengthy examination time.
My condition Stargardt Disease
, which has been with me since birth, gives only slight peripheral vision in my left eye.
22 March 2011 - UK-based gene therapy company Oxford BioMedica plc (LON: OXB) announced yesterday that the US Food and Drug Administration (FDA) has approved its Investigational New Drug (IND) application for the Phase I/IIa clinical development of StarGen, a novel gene-based treatment for Stargardt disease
The factors accounting for the preservation of the fovea in atrophic disorders are not well understood, but foveal preservation is also present in a number of other conditions, including Stargardt disease
, cone dystrophy, central areolar choroidal dystrophy, and plaquenil toxicity (Gass, 1997).