SH3 domain

(redirected from Src homology 3 domain)

SH3 domain

Src-homology 3 domain. A small, circa-60-amino acid domain which binds to proline-rich peptides. Proteins with SH3 domain include CDC24, CDC25, crk adaptor protein, cytoplasmic tyrosine kinases—e.g., abl, src, phospholipase, PI3 kinase, Ras GTPase activating protein.