SH2 domain

(redirected from Src homology 2 domain-containing)

SH2 domain

A modular, circa-100-amino acid domain which binds to specific phospho-containing peptide motifs; SH2 is found in adaptors, kinases, phosphatase, Ras signalling, scaffolds, transcription, ubiquination. It is involved in cytoskeletal regulation, phospholipid second messenger signalling, and in signal regulation.
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References in periodicals archive ?
(2004) Association between diversity in the Src homology 2 domain-containing tyrosine phosphatase binding site of Helicobacter pylori CagA protein and gastric atrophy and cancer.
Background: Src homology 2 domain-containing protein tyrosine phosphatase-2 (SHP-2) is a kind of intracellular protein tyrosine phosphatase.
The Src homology 2 domain-containing protein tyrosine phosphatase-2 (SHP-2), characterized by two N-terminal Src homology 2 domains, a central catalytic domain and a C-terminal protein tyrosine phosphatase (PTP) domain, is an evolutionarily conserved intracellular PTP.
Identification of Src homology 2 domain-containing protein tyrosine phosphatase-2 gene conditionally knocked-out in myeloid cells
Src homology 2 domain-containing protein tyrosine phosphatase-2 gene conditionally knocked-out results in reduced macrophage infiltration after unilateral ureter obstruction
Src homology 2 domain-containing protein tyrosine phosphatase-2 gene conditionally knocked-out prevents pro-inflammatory cytokines production after unilateral ureter obstruction